Frequency of single nucleotide polymorphisms of some immune response genes in a population sample from São Paulo, Brazil

Author(s)

Léa Campos de Oliveira ; Rajendranath Ramasawmy ^[2] ; Jaila Dias Borges ^[3] ; Maria Lucia Carnevale Marin ^[4] ; Natalie Guida Muller ^[5] ; Jorge Kalil ; Anna Carla Goldberg

• Document type: Journal article
• Source: Einstein (São Paulo); v. 9, n. 3, p. 359-366, 2011-09-00.

Abstract

ABSTRACT Objective: To present the frequency of single nucleotide polymorphisms of a few immune response genes in a population sample from São Paulo City (SP), Brazil. Methods: Data on allele frequencies of known polymorphisms of innate and acquired immunity genes were presented, the majority with proven impact on gene function. Data were gathered from a sample of healthy individuals, non-HLA identical siblings of bone marrow transplant recipients from the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, obtained between 1998 and 2005. The number of samples varied for each single nucleotide polymorphism analyzed by polymerase chain reaction followed by restriction enzyme cleavage. Results: Allele and genotype distribution of 41 different gene polymorphisms, mostly cytokines, but also including other immune response genes, were presented. Conclusion: We believe that the data presented here can be of great value for case-control studies, to define which polymorphisms are present in biologically relevant frequencies and to assess targets for therapeutic intervention in polygenic diseases with a component of immune and inflammatory responses. (AU)

• FAPESP's process: 05/00553-3 - Susceptibility genes in autoimmune hepatitis
• Grantee: Gilda Porta
• Support Opportunities: Regular Research Grants
• FAPESP's process: 01/09850-0 - Genetic Polymorphism of the immune response in humans: studies by genotyping and gene expression analysis
• Grantee: Anna Carla Renata Krepel Goldberg
• Support Opportunities: Research Projects - Thematic Grants