| Full text | |
| Author(s): |
Nascimento, Camila
[1]
;
Suemoto, Claudia K.
[2, 3]
;
Rodriguez, Roberta D.
[1]
;
Di Lorenzo Alho, Ana Tereza
[4, 5]
;
Leite, Renata P.
[2, 3]
;
Farfel, Jose Marcelo
[2, 3]
;
Goncalves Pasqualucci, Carlos Augusto
[6, 3]
;
Jacob-Filho, Wilson
[2, 3]
;
Grinberg, Lea T.
[6, 3, 7]
Total Authors: 9
|
| Affiliation: | [1] Univ Sao Paulo, Sch Med, Discipline Expt Pathophysiol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Div Geriatr, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Brazilian Aging Brain Study Grp, LIM 22, Sao Paulo - Brazil
[4] Hosp Israelita Albert Einstein, Inst Cerebro, Sao Paulo - Brazil
[5] Univ Sao Paulo, Sch Med, Dept Radiol, Sao Paulo - Brazil
[6] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo - Brazil
[7] Univ Calif San Francisco, Dept Neurol & Pathol, Memory & Aging Ctr, San Francisco, NC - USA
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | Brain Pathology; v. 26, n. 2, p. 177-185, MAR 2016. |
| Web of Science Citations: | 13 |
| Abstract | |
Transactive response DNA binding protein 43 (TDP-43) proteinopathy is the major hallmark of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. It is also present in a subset of Alzheimer's disease cases. Recently, few reports showed TDP-43 changes in cognitively normal elderly. In Caucasians, TDP-43 proteinopathy independently correlate with cognitive decline. However, it is challenging to establish direct links between cognitive and/or neuropsychiatric symptoms and protein inclusions in neurodegenerative diseases because individual cognitive reserves modify the threshold for clinical disease expression. Cognitive reserve is influenced by demographic, environmental and genetic factors. We investigated the relationships between demographic, clinical and neuropathological variables and TDP-43 proteinopathy in a large multiethnic sample of cognitively normal elderly. TDP-43 proteinopathy was identified in 10.5%, independently associated with older age (P=0.03) and Asian ethnicity (P=0.002). Asians showed a higher prevalence of TDP-43 proteinopathy than Caucasians, even after adjustment for sex, age, Braak stage and schooling (odds ratio=3.50, confidence interval 1.41-8.69, P=0.007). These findings suggested that Asian older adults may be protected from the clinical manifestation of brain TDP-43 proteinopathy. Future studies are needed to identify possible race-related protective factors against clinical expression of TDP-43 proteinopathies. (AU) | |
| FAPESP's process: | 11/19833-7 - Characterization of TDP-43 changes during normal aging: a postmortem study |
| Grantee: | Camila Nascimento Mantelli |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 10/06521-4 - Proteomic analysis of neuromelanin granules in normal aging and Parkinson disease |
| Grantee: | Renata Elaine Paraizo Leite |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 12/07526-5 - Argyrophilic grain disease |
| Grantee: | Roberta Diehl Rodriguez |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |