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Structural and functional Papez circuit integrity and its relations to symptomology in Amyotrophic Lateral Sclerosis

Grant number: 16/19376-9
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2017
Effective date (End): February 29, 2020
Field of knowledge:Interdisciplinary Subjects
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:João Ricardo Sato
Grantee:Ana Paula Arantes de Andrade Bueno
Host Institution: Centro de Matemática, Computação e Cognição (CMCC). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
Associated scholarship(s):17/23020-8 - Papez circuit integrity and memory performance in ALS: development of a novel tool to assess episodic memory performance., BE.EP.DR

Abstract

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are multisystem neurodegenerative disorders with overlapping clinical and pathological characteristics and lie, therefore, on a disease continuum. ALS was historically seen as a "pure" motor function disease, however many patients can present with full-blown dementia (ALS-FTD) or more subtle behavioural and cognitive changes. Importantly, ALS and FTD also share the same underlying proteinopathy with immunoreactive inclusions of TDP-43 in many brain areas, but often focused around the temporal lobes. This is nicely corroborated by neuroimaging studies showing grey and white matter changes in the same brain regions. Recent studies in FTD highlight that these temporal lobe changes, including the Papez circuit, can be severely affected in the patients and can cause significant symptoms, such as episodic memory and emotion recognition deficits. To our knowledge, however, despite the reports of memory and emotional processing deficits, as well as structural changes in the hippocampus and frontotemporal regions in ALS patients, none of the studies has investigated the integrity of the complete classical neural circuit of anatomic substrates for memory processing and emotions: the Papez circuit. We aim to investigate the integrity of gray matter and white matter of the Papez circuit in ALS patients using voxel-based morphometry (VBM) analysis and diffusion tensor imaging (DTI) and compare to controls and FTD patients. Further, we will investigate how functional connectivity might be also affected across the circuit in the ALS patients compared to controls. The objective is to identify if there is a pattern of structural and functional brain changes in ALS patients and how it relates to the symptomology, in particular in regards to memory and emotion recognition. These findings will not only improve diagnosis and management of ALS but also will allow potentially to be used as an outcome measure for future intervention studies. In turn, this will allow better clinical service provision, as well as better management of the disease for patients and their families (AU)

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SATO, JOAO RICARDO; BIAZOLI, CLAUDINEI EDUARDO; ZUGMAN, ANDRE; PAN, PEDRO MARIO; ARANTES BUENO, ANA PAULA; MOURA, LUCIANA MONTEIRO; GADELHA, ARY; PICON, FELIPE ALMEIDA; AMARO JR, EDSON; SALUM, GIOVANNI ABRAHAO; et al. Long-term stability of the cortical volumetric profile and the functional human connectome throughout childhood and adolescence. European Journal of Neuroscience, v. 54, n. 6, . (18/21934-5, 16/19376-9, 13/08531-5, 14/50917-0, 18/04654-9)
ARANTES BUENO, ANA PAULA; DE SOUZA, LEONARDO CRUZ; LOPEZ PINAYA, WALTER HUGO; TEIXEIRA, ANTONIO LUCIO; ROUSSEFF DE PRADO, LAURA GODOY; CARAMELLI, PAULO; HORNBERGER, MICHAEL; SATO, JOAO RICARDO. Papez Circuit Gray Matter and Episodic Memory in Amyotrophic Lateral Sclerosis and Behavioural Variant Frontotemporal Dementia. BRAIN IMAGING AND BEHAVIOR, v. 15, n. 2, p. 11-pg., . (16/19376-9)
ARANTES BUENO, ANA PAULA; PINAYA, WALTER HUGO L.; MOURA, LUCIANA M.; BERTOUX, MAXIME; RADAKOVIC, RATKO; KIERNAN, MATTHEW C.; TEIXEIRA, ANTONIO LUCIO; DE SOUZA, LEONARDO CRUZ; HORNBERGER, MICHAEL; SATO, JOAO RICARDO. Structural and functional papez circuit integrity in amyotrophic lateral sclerosis. BRAIN IMAGING AND BEHAVIOR, v. 12, n. 6, p. 1622-1630, . (16/19376-9)
ARANTES BUENO, ANA PAULA; LOPEZ PINAYA, WALTER HUGO; REBELLO, KEILA; DE SOUZA, LEONARDO CRUZ; HORNBERGER, MICHAEL; SATO, JOAO RICARDO. Regional Dynamics of the Resting Brain in Amyotrophic Lateral Sclerosis Using Fractional Amplitude of Low-Frequency Fluctuations and Regional Homogeneity Analyses. BRAIN CONNECTIVITY, v. 9, n. 4, p. 356-364, . (16/19376-9)
AMBRIOLA OKU, AMANDA YUMI; ZIMEO MORAIS, GUILHERME AUGUSTO; ARANTES BUENO, ANA PAULA; FUJITA, ANDRE; SATO, JOAO RICARDO. Potential Confounders in the Analysis of Brazilian Adolescent's Health: A Combination of Machine Learning and Graph Theory. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 17, n. 1, . (19/17907-5, 18/21934-5, 16/19376-9, 18/04654-9)
REBELLO, KEILA; MOURA, LUCIANA MONTEIRO; ARANTES BUENO, ANA PAULA; PICON, FELIPE ALMEIDA; PAN, PEDRO MARIO; GADELHA, ARY; MIGUEL, EURIPEDES CONSTATINO; BRESSAN, RODRIGO AFFONSECA; ROHDE, LUIS AUGUSTO; SATO, JOAO RICARDO. Associations between Family Functioning and Maternal Behavior on Default Mode Network Connectivity in School-Age Children. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 19, n. 10, p. 10-pg., . (21/05332-8, 18/04654-9, 14/50917-0, 16/19376-9, 18/21934-5)
ARANTES BUENO, ANA PAULA; DE SOUZA, LEONARDO CRUZ; LOPEZ PINAYA, WALTER HUGO; TEIXEIRA, ANTONIO LUCIO; ROUSSEFF DE PRADO, LAURA GODOY; CARAMELLI, PAULO; HORNBERGER, MICHAEL; SATO, JOAO RICARDO. Papez Circuit Gray Matter and Episodic Memory in Amyotrophic Lateral Sclerosis and Behavioural Variant Frontotemporal Dementia. BRAIN IMAGING AND BEHAVIOR, v. 15, n. 2, SI, . (16/19376-9)
BUENO, A. P. A.; SATO, J. R.; HORNBERGER, M.. Eye tracking - The overlooked method to measure cognition in neurodegeneration?. Neuropsychologia, v. 133, . (18/21934-5, 17/23020-8, 16/19376-9, 18/04654-9)

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