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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Regional Dynamics of the Resting Brain in Amyotrophic Lateral Sclerosis Using Fractional Amplitude of Low-Frequency Fluctuations and Regional Homogeneity Analyses

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Arantes Bueno, Ana Paula [1, 2] ; Lopez Pinaya, Walter Hugo [1, 3] ; Rebello, Keila [1] ; de Souza, Leonardo Cruz [4] ; Hornberger, Michael [2, 5] ; Sato, Joao Ricardo [1]
Total Authors: 6
[1] Univ Fed ABC, Ctr Math Comp & Cognit, Santo Andre - Brazil
[2] Univ East Anglia, Norwich Med Sch, Dept Med, Norwich, Norfolk - England
[3] Kings Coll London, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci, London - England
[4] Univ Fed Minas Gerais, Dept Internal Med, Belo Horizonte, MG - Brazil
[5] Norfolk & Suffolk NHS Fdn Trust, Norwich, Norfolk - England
Total Affiliations: 5
Document type: Journal article
Source: BRAIN CONNECTIVITY; v. 9, n. 4, p. 356-364, MAY 1 2019.
Web of Science Citations: 1

Resting-state functional magnetic resonance imaging has been playing an important role in the study of amyotrophic lateral sclerosis (ALS). Although functional connectivity is widely studied, the patterns of spontaneous neural activity of the resting brain are important mechanisms that have been used recently to study a variety of conditions but remain less explored in ALS. Here we have used fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo) to study the regional dynamics of the resting brain of nondemented ALS patients compared with healthy controls. As expected, we found the sensorimotor network with changes in fALFF and ReHo, and also found the default mode network (DMN), frontoparietal network (FPN), and salience network (SN) altered and the cerebellum, although no structural changes between ALS patients and controls were reported in the regions with fALFF and ReHo changes. We show an altered pattern in the spontaneous low-frequency oscillations that is not confined to the motor areas and reveal a more widespread involvement of nonmotor regions, including those responsible for cognition. (AU)

FAPESP's process: 16/19376-9 - Structural and functional Papez circuit integrity and its relations to symptomology in Amyotrophic Lateral Sclerosis
Grantee:Ana Paula Arantes de Andrade Bueno
Support type: Scholarships in Brazil - Doctorate