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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Participation of alpha(2)-adrenoceptors in sodium appetite inhibition during sickness behaviour following administration of lipopolysaccharide

Full text
Author(s):
De Luca, Jr., Laurival A. [1] ; Almeida, Roberto L. [2] ; David, Richard B. [1] ; de Paula, Patricia M. [1] ; Andrade, Carina A. F. [1] ; Menani, Jose V. [1]
Total Authors: 6
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Dent, Dept Physiol & Pathol, Sao Paulo - Brazil
[2] ABC Med Sch, Dept Physiol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: JOURNAL OF PHYSIOLOGY-LONDON; v. 594, n. 6, p. 1607-1616, MAR 15 2016.
Web of Science Citations: 0
Abstract

Sickness behaviour, a syndrome characterized by a general reduction in animal activity, is part of the active-phase response to fight infection. Lipopolysaccharide (LPS), an effective endotoxin to model sickness behaviour, reduces thirst and sodium excretion, and increases neurohypophysial secretion. Here we review the effects of LPS on thirst and sodium appetite. Altered renal function and hydromineral fluid intake in response to LPS occur in the context of behavioural reorganization, which manifests itself as part of the syndrome. Recent data show that, in addition to its classical effect on thirst, non-septic doses of LPS injected intraperitoneally produce a preferential inhibition of intracellular thirst versus extracellular thirst. Moreover, LPS also reduced hypertonic NaCl intake in sodium-depleted rats that entered a sodium appetite test. Antagonism of (2)-adrenoceptors abolished the effect of LPS on sodium appetite. LPS and cytokine transduction potentially recruit brain noradrenaline and (2)-adrenoceptors to control sodium appetite and sickness behaviour. (AU)

FAPESP's process: 03/09857-0 - Neuroendocrine mechanisms of the regulation of the hypothalamic-pituitary-adrenal axis in clinical and experimental models of resistance to glycocorticoids and sepsis
Grantee:Ayrton Custodio Moreira
Support Opportunities: PRONEX Research - Thematic Grants
FAPESP's process: 11/50770-1 - Neural mechanisms involved of hydroelectrolytic balance and cardiorespiratory control
Grantee:José Vanderlei Menani
Support Opportunities: Research Projects - Thematic Grants