Role of lateral parabrachial nucleus and forebrain angiotensinergic receptors in the control of hydro mineral balance during primary hypertension.

• Grant number: 15/20500-3
• Support Opportunities: Regular Research Grants
• Duration: March 01, 2017 - February 28, 2019
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Carina Aparecida Fabrício de Andrade
• Grantee: Carina Aparecida Fabrício de Andrade
• Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated researchers: José Vanderlei Menani

Abstract

Excessive salt intake has been associated with the development or worsening of chronic diseases, including hypertension. The lateral parabrachial nucleus (LPBN) is an important inhibitory mechanism for sodium intake control and it is involved in cardiovascular control. Spontaneously hypertensive rats (SHR), an animal model for the study of primary hypertension, show an increased preference for sodium when compared to normotensive strains. Considering that the LPBN contribution to sodium appetite and cardiovascular control is still unknown in SHR, our first objective is to evaluate the effects of alpha2 adrenergic activation of LPBN on cardiovascular parameters and sodium appetite in SHR. Our recent results show that SHR have an increased palatability to sodium compared to normotensive rats, suggesting the increase in hedonic properties of sodium may contribute to high consumption of sodium. Thus, our second objective is to verify the importance of forebrain AT1R receptors on the increased hypertonic sodium palatability in SHR compared to normotensive rats. Additionally, it will be investigated whether selective inhibition of angiotensin II-induced Erk 1/2 activation would change sodium intake and palatability and cardiovascular parameters in SHR. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PEREIRA, JR., E. D.; DANTAS, R. M.; ANDRADE-FRANZE, G. M. F.; DE LUCA, JR., L. A.; MENANI, J. V.; ANDRADE, C. A. F.. Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetite. APPETITE, v. 133, p. 252-261, FEB 1 2019. (15/20500-3)

PEREIRA, E. D., JR.; OLIVEIRA, L. M.; COLETTO-NUNES, G.; SOUZA, P. P. C.; MENANI, J., V; DE LUCA, L. A.; ANDRADE, C. A. F.. Central angiotensinergic mechanisms in female spontaneously hypertensive rats treated with estradiol. APPETITE, v. 174, p. 11-pg., 2022-07-01. (15/20500-3)

ZENATTI, A. A.; PEREIRA JR, E. D.; POSSARI, J.; ANDRADE, C. A. F.; MENANI, V, J.; DE LUCA JR, L. A.. Interference with the renin-angiotensin system reduces the palatability of 0.3 M NaCl in sodium-deplete rats. APPETITE, v. 158, MAR 1 2021. (15/23467-7, 11/50770-1, 19/01220-0, 15/20500-3)

ANDRADE-FRANZE, G. M. F.; PEREIRA JR, E. D.; YOSTEN, G. L. C.; SAMSON, W. K.; MENANI, J. V.; DE LUCA JR, L. A.; ANDRADE, C. A. F.. Blockade of ERK1/2 activation with U0126 or PEP7 reduces sodium appetite and angiotensin II-induced pressor responses in spontaneously hypertensive rats. Peptides, v. 136, FEB 2021. (15/20500-3)

PEREIRA, E. D.; FARIA, A. M.; ANDRADE-FRANZE, G. M. F.; MENANI, V, J.; DE LUCA, L. A.; ANDRADE, C. A. F.. Sodium palatability in male spontaneously hypertensive rats. Hormones and Behavior, v. 130, APR 2021. (15/20500-3)

RODRIGUES FERNANDES, NATALIE APARECIDA; SANTOS, BRUNA MAITAN; FABRICIO DE ANDRADE-FRANZE, GLAUCIA MARIA; DE PAULA, PATRICIA MARIA; FABRICIO DE ANDRADE, CARINA APARECIDA; MENANI, JOSE VANDERLEI; DE LUCA JR, LAURIVAL ANTONIO. Rapid onset sodium appetite and orofacial responses to intraoral capsaicin and hypertonic NaCl in the rat. APPETITE, v. 174, p. 6-pg., 2022-04-09. (15/20500-3, 11/50770-1)