Molecularly Imprinted Polymer-Decorated Magnetite Nanoparticles for Selective Sulfonamide Detection

Author(s)

Zamora-Galvez, Alejandro ^{[1, 2]} ; Ait-Lahcen, Abdellatif ^{[1, 2, 3]} ; Mercante, Luiza A. ^{[1, 2, 4]} ; Morales-Narvaez, Eden ^{[1, 2]} ; Amine, Aziz ^[3] ; Merkoci, Arben ^{[5, 1, 2]}

Affiliation

^[1] CSIC, Catalan Inst Nanosci & Nanotechnol ICN2, Campus UAB, Barcelona 08193 - Spain

^[2] Barcelona Inst Sci & Technolgy, Campus UAB, Barcelona 08193 - Spain

^[3] Hassan II Univ Casablanca, Fac Sci & Tech, BP146, Mohammadia 20650 - Morocco

^[4] Natl Lab Nanotechnol Agribusiness LNNA, Embrapa Instrumentat, BR-13560970 Sao Carlos, SP - Brazil

^[5] ICREA Catalan Inst Res & Adv Studies, Barcelona 08010 - Spain

• Document type: Journal article
• Source: Analytical Chemistry; v. 88, n. 7, p. 3578-3584, APR 5 2016.
• Web of Science Citations: 49

Abstract

Sulfonamides are known not only to be antimicrobial drugs that lead to antimicrobial resistance but also to be chemotherapeutic agents that may be allergenic and potentially carcinogenic, which represents a potentially hazardous compound once present in soil or water. Herein, a hybrid material based on molecularly imprinted polymer (MIP) decorated magnetite nanoparticles for specific and label-free sulfonamide detection is reported. The composite has been characterized using different spectroscopic and imaging techniques. The magnetic properties of the composite are used to separate, preconcentrate, and manipulate the analyte which is selectively captured by the MIP onto the surface of the composite. Screen printed electrodes have been employed to monitor the impedance levels of the whole material, which is related to the amount of the captured analyte, via electrochemical impedance spectroscopy. This composite-based sensing system exhibits an extraordinary limit of detection. of 1 X 10(-12) mol L-1 (2.8 X 10(-4) ppb) (S/N = 3), which is close to those obtained with liquid chromatography and mass spectrometry, and it was demonstrated to screen sulfamethoxazole in a complex matrix such as seawater, where according to the literature sulfonamides content is minimum compared with other environmental samples. (AU)

• FAPESP's process: 14/26088-4 - Development of novel nanocomposites for diagnostic and security monitoring platforms
• Grantee: Luiza Amim Mercante
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor