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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Functionalized Silica Nanoparticles As an Alternative Platform for Targeted Drug-Delivery of Water Insoluble Drugs

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Author(s):
de Oliveira, Luciane Franca [1] ; Bouchmella, Karim [1] ; Goncalves, Kaliandra de Almeida [2] ; Bettini, Jefferson [3] ; Kobarg, Joerg [4, 5] ; Cardoso, Mateus Borba [1]
Total Authors: 6
Affiliation:
[1] Lab Nacl Luz Sincrotron, Caixa Postal 6192, BR-13083970 Campinas, SP - Brazil
[2] Lab Nacl Biociencias LNBio, Caixa Postal 6192, BR-13083970 Campinas, SP - Brazil
[3] Lab Nacl Nanotecnol LNNano, Caixa Postal 6192, BR-13083970 Campinas, SP - Brazil
[4] Univ Estadual Campinas, UNICAMP, Fac Ciencias Farmaceut, Caixa Postal 6154, BR-13083970 Campinas, SP - Brazil
[5] Univ Estadual Campinas, UNICAMP, Inst Biol, Dept Bioquim & Biol Tecidual, Caixa Postal 6154, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Langmuir; v. 32, n. 13, p. 3217-3225, APR 5 2016.
Web of Science Citations: 34
Abstract

The selective action of drugs in tumor cells is a major problem in cancer therapy. Most chemotherapy drugs act nonspecifically and damage both cancer and healthy cells causing various side effects. In this study, the preparation of a selective drug delivery system, which is able to act as a carrier for hydrophobic and anticancer drugs is reported. Amino-functionalized silica nanoparticles loaded with curcumin were successfully synthesized via sol-gel approach and duly characterized. Thereafter, the targeting ligand, folate, was covalently attached to amino groups of nanoparticle surface through amide bond formation. The cytotoxic effect of nanoparticles on prostate cancer cells line was evaluated and compared to normal cells line (prostate epithelial cell). Cytotoxicity experiments demonstrated that folate-functionalized nanoparticles were significantly cytotoxic to tumor cells, whereas normal cells were much less affected by the presence of these structures. (AU)

FAPESP's process: 14/22322-2 - Functionalization of silica nanoparticles: increasing biological interaction
Grantee:Mateus Borba Cardoso
Support type: Regular Research Grants