Microparticles Containing Curcumin Solid Dispersion: Stability, Bioavailability and Anti-Inflammatory Activity

Author(s)

Teixeira, C. C. C. ^[1] ; Mendonca, L. M. ^[1] ; Bergamaschi, M. M. ^[1] ; Queiroz, R. H. C. ^[1] ; Souza, G. E. P. ^[1] ; Antunes, L. M. G. ^[1] ; Freitas, L. A. P. ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Via Cafe S-N, Campus USP, BR-14040903 Ribeirao Preto - Brazil

• Document type: Journal article
• Source: AAPS PHARMSCITECH; v. 17, n. 2, p. 252-261, APR 2016.
• Web of Science Citations: 20

Abstract

This work aimed at improving the solubility of curcumin by the preparation of spray-dried ternary solid dispersions containing GelucireA (R) 50/13-AerosilA (R) and quantifying the resulting in vivo oral bioavailability and anti-inflammatory activity. The solid dispersion containing 40% of curcumin was characterised by calorimetry, infrared spectroscopy and X-ray powder diffraction. The solubility and dissolution rate of curcumin in aqueous HCl or phosphate buffer improved up to 3600- and 7.3-fold, respectively. Accelerated stability test demonstrated that the solid dispersion was stable for 9 months. The pharmacokinetic study showed a 5.5-fold increase in curcumin in rat blood plasma when compared to unprocessed curcumin. The solid dispersion also provided enhanced anti-inflammatory activity in rat paw oedema. Finally, the solid dispersion proposed here is a promising way to enhance curcumin bioavailability at an industrial pharmaceutical perspective, since its preparation applies the spray drying, which is an easy to scale up technique. The findings herein stimulate further in vivo evaluations and clinical tests as a cancer and Alzheimer chemoprevention agent. (AU)

• FAPESP's process: 11/20872-7 - Development and application of the spray freeze drying technique for phytopharmaceutical products
• Grantee: Luis Alexandre Pedro de Freitas
• Support Opportunities: Regular Research Grants