| Full text | |
| Author(s): |
Vasconcelos, Stanley N. S.
[1]
;
Drewes, Carine C.
[2]
;
Kanda Kupa, Leonard de Vinci
[2]
;
Farsky, Sandra H. P.
[2]
;
Stefani, Helio A.
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Sao Paulo, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; v. 114, p. 1-7, MAY 23 2016. |
| Web of Science Citations: | 3 |
| Abstract | |
We report a method to obtain biaryl dipeptide tyrosine via Suzuki-Miyaura and alkynyl dipeptide tyrosine by Sonogashira cross-coupling reactions. Analysis of the biological action of biaryl dipeptide tyrosine 4d compound showed its ability to impair the metabolism and proliferation of SK-Mel-28 human melanoma lineage cells, independently of mitochondrial membrane depolarization, apoptosis and necrosis. Moreover, 4d compound did not cause toxicity to human umbilical vein endothelial cells (HUVEC), suggesting its toxic specificity to cancer cells. (C) 2016 Elsevier Masson SAS. All rights reserved. (AU) | |
| FAPESP's process: | 12/00424-2 - Synthesis of small libraries using potassium Organotrifluoroborates in Suzuki-Miyaura reactions |
| Grantee: | Helio Alexandre Stefani |
| Support type: | Research Projects - Thematic Grants |
| FAPESP's process: | 10/19802-1 - Effects of lipid-core nanocapsules with acetyleugenol in melanomas: in vivo and in vitro studies |
| Grantee: | Carine Cristiane Drewes |
| Support type: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 13/17960-7 - Functionalization of 3-iodo-(L)-Tyrosine via Suzuki-Miyaura Reaction Using Potassium Organotrifluoroborate salts |
| Grantee: | Stanley Nunes Siqueira Vasconcelos |
| Support type: | Scholarships in Brazil - Doctorate |