Paradoxical Roles of the neutrophil in Sepsis: Protective and Deleterious

Author(s)

Sonego, Fabiane ^{[1, 2]} ; Castanheira, Fernanda Vargas e Silva ^[1] ; Ferreira, Raphael Gomes ^[1] ; Kanashiro, Alexandre ^[1] ; Vitorino Goncalves Leite, Caio Abner ^[1] ; Nascimento, Daniele Carvalho ^[1] ; Colon, David Fernando ^[3] ; Borges, Vanessa de Fatima ^[1] ; Alves-Filho, Jose Carlos ^[1] ; Cunha, Fernando Queiroz ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Farmacol, BR-14049 Ribeirao Preto - Brazil

^[2] Inst Pasteur, Imagopole, Paris - France

^[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Bioquim & Imunol, BR-14049 Ribeirao Preto - Brazil

• Document type: Review article
• Source: FRONTIERS IN IMMUNOLOGY; v. 7, APR 26 2016.
• Web of Science Citations: 37

Abstract

Sepsis, an overwhelming inflammatory response syndrome secondary to infection, is one of the costliest and deadliest medical conditions worldwide. Neutrophils are classically considered to be essential players in the host defense against invading pathogens. However, several investigations have shown that impairment of neutrophil migration to the site of infection, also referred to as neutrophil paralysis, occurs during severe sepsis, resulting in an inability of the host to contain and eliminate the infection. On the other hand, the neutrophil antibacterial arsenal contributes to tissue damage and the development of organ dysfunction during sepsis. In this review, we provide an overview of the main events in which neutrophils play a beneficial or deleterious role in the outcome of sepsis. (AU)

• FAPESP's process: 08/11593-4 - PARTICIPATION OF NOD-LIKE RECEPTORS ON INFLAMMATORY RESPONSE IN POLYMICROBIAL SEPSIS
• Grantee: Fabiane Sônego
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 11/19670-0 - Mechanisms involved in the pathophysiology of rheumatoid arthritis, pain and sepsis
• Grantee: Fernando de Queiroz Cunha
• Support Opportunities: Research Projects - Thematic Grants