Interferon lambda and hepatitis C virus core protein polymorphisms associated with liver cancer

Author(s):Show less -

Moreira, Joao Paulo ^{[1, 2]} ; Malta, Fernanda de Mello ^{[1, 2]} ; Diniz, Marcio Augusto ^{[2, 3]} ; Kikuchi, Luciana ^[2] ; Chagas, Aline Lopes ^[2] ; Botelho Lima, Livia de Souza ^{[1, 2]} ; Gomes-Gouvea, Michele Soares ^{[1, 2]} ; Duarte de Castro, Vanessa Fusco ^[4] ; Ferraz Santana, Rubia Anita ^[4] ; Sumita, Nairo Massakazu ^[5] ; Paranagua Vezozzo, Denise Cerqueira ^[2] ; Carrilho, Flair Jose ^[2] ; Rebello Pinho, Joao Renato ^{[4, 1, 2]}

Affiliation

^[1] Univ Sao Paulo, Inst Trop Med, Lab Trop Gastroenterol & Hepatol Joao Alves de Qu, LIM 07, BR-05403000 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Sch Med, Dept Gastroenterol, BR-05403000 Sao Paulo, SP - Brazil

^[3] Cedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 - USA

^[4] Hosp Israelita Albert Einstein, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Cent Lab, Div Hosp Clin, Sch Med, BR-05403000 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: VIROLOGY; v. 493, p. 136-141, JUN 2016.
• Web of Science Citations: 3

Abstract

Background: Hepatitis C virus (HCV) infection is often persistent and gradually advances from chronic hepatitis to liver cirrhosis and hepatocellular carcinoma (HCC). Worldwide, hepatocellular carcinoma is the fifth most common neoplasm. Method of study: the Interferon lambda (IFNL) polymorphisms genotypes (rs8099917, rs12979860 and rs12980275) and the presence of mutations in HCV core protein were analyzed in 59 patients with HCC, and also in 50 cirrhotic patients (without HCC). Results: the rs12980275-AG genotype was associated with HCC on age-adjusted analysis (OR 2.42, 95% CI 1.03-5.69, P=0.043). Core substitutions R70Q and L91M were mainly found in genotype 1b isolates. Furthermore, a borderline level of statistical significance association was found among the presence of amino acid Glutamine (Q) in the position 70 and IFNL3 genotype AG (P=0.054). Conclusions: the screening of these polymorphisms and functional studies would be useful in clinical practice for identifying groups at high risk of HCC development. (C) 2016 Elsevier Inc. All rights reserved. (AU)