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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluation of peritoneal endometriosis treatment using intralesional acetylsalicylic acid injection in rabbits

Full text
Author(s):
Rogério Saad-Hossne [1] ; Adriana Beatriz Barretto [2] ; Juliana Menezes Siqueira [3] ; Rafael Denadai [4]
Total Authors: 4
Affiliation:
[1] Universidade Estadual de São Paulo. Botucatu Medical School - Brasil
[2] UNESP. FMB - Brasil
[3] UNESP. FMB - Brasil
[4] UNESP. FMB - Brasil
Total Affiliations: 4
Document type: Journal article
Source: Acta Cirurgica Brasileira; v. 31, n. 4, p. 227-234, 2016-04-00.
Abstract

PURPOSE: To investigate the efficacy of intralesional 20% aspirin injection for treatment of experimental peritoneal endometriosis. Methods: Peritoneal endometriosis was experimentally induced in forty adult nulligravid female rabbits. On day 30 post-endometriosis induction, rabbits were randomly divided to assess early (10 days) and late (20 days) effects of intralesional injection of physiological saline solution (control groups) in comparison to intralesional injection of 20% bicarbonate aspirin solution (experimental groups) as follows: control group 1 (10 days, n=10); control group 2 (20 days, n=10); experimental group 3 (10 days, n=10); experimental group 4 (20 days, n=10). Resected tissues, including endometriosis foci, were qualitatively (general morphology and signs of inflammatory cells infiltrate, necrosis and apoptosis) and quantitatively (remaining endometriosis area) assessed by histopathological analysis. Results: Extensive necrosis, hemorrhage, apoptosis, and fibrosis were observed in the experimental groups 3 and 4. Groups 1 and 2 presented typical endometrial tissue cysts, respectively. Groups 3 and 4 showed sparse endometrial tissue foci and no endometrial tissue, respectively. Quantitative analysis revealed that aspirin-treated groups 3 and 4 had significantly (p<0.05) smaller remaining endometriosis area, compared to control groups 1 and 2. Conclusion: Intralesional 20% aspirin injection caused total destruction of peritoneal endometriosis foci in rabbits. (AU)

FAPESP's process: 10/00552-5 - The effects of injecting aspirin in peritoneal endometriosis foci in rabbits
Grantee:Rogério Saad Hossne
Support Opportunities: Regular Research Grants