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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dendrimer Prodrugs

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Author(s):
Santos, Soraya da Silva [1] ; Ferreira, Elizabeth Igne [1] ; Giarolla, Jeanine [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Lab Design & Synth Chemotherapeut Potentially Act, Dept Pharm, Fac Pharmaceut Sci, Ave Prof Lineu Prestes 580 Bldg 13, BR-05508900 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: Molecules; v. 21, n. 6 JUN 2016.
Web of Science Citations: 5
Abstract

The main objective of this review is to describe the importance of dendrimer prodrugs in the design of new drugs, presenting numerous applications of these nanocomposites in the pharmaceutical field. Therefore, the use of dendrimer prodrugs as carrier for drug delivery, to improve pharmacokinetic properties of prototype, to promote drug sustained-release, to increase selectivity and, consequently, to decrease toxicity, are just some examples of topics that have been extensively reported in the literature, especially in the last decade. The examples discussed here give a panel of the growing interest dendrimer prodrugs have been evoking in the scientific community. (AU)

FAPESP's process: 12/19031-0 - Potential antichagasics and leishmanicides: synthesis of dendrimer prodrugs of 3-hydroxyflavone
Grantee:Soraya da Silva Santos
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 15/19438-1 - Synthesis and studies of bioactive compounds release from dendrimer prodrugs and targeted drugs potentially active in neglected diseases
Grantee:Jeanine Giarolla Vargas
Support Opportunities: Regular Research Grants