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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bone Mineral Density and Parathyroid Hormone as Independent Risk Factors for Mortality in Community-Dwelling Older Adults: A Population-Based Prospective Cohort Study in Brazil. The SAo Paulo Ageing & Health (SPAH) Study

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Author(s):
Domiciano, Diogo S. [1] ; Machado, Luana G. [1] ; Lopes, Jaqueline B. [1] ; Figueiredo, Camille P. [1] ; Caparbo, Valeria F. [1] ; Oliveira, Ricardo M. [2] ; Scazufca, Marcia [3] ; McClung, Michael R. [4] ; Pereira, Rosa M. R. [1]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Fac Med, Div Rheumatol, Bone Metab Lab, BR-01246903 Sao Paulo, SP - Brazil
[2] RDO Diagnost Med, Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med, Dept Prevent Med, BR-01246903 Sao Paulo, SP - Brazil
[4] Oregon Osteoporosis Ctr, Portland, OR - USA
Total Affiliations: 4
Document type: Journal article
Source: Journal of Bone and Mineral Research; v. 31, n. 6, p. 1146-1157, JUN 2016.
Web of Science Citations: 11
Abstract

Previous studies have shown a relationship between osteoporosis and increased mortality risk. However, none of these studies performed a concomitant evaluation of the parathyroid hormone (PTH)-calcium-vitamin D axis and bone mass to accurately determine the contribution of each of these parameters to survival in older subjects. Thus, we sought to investigate the association between bone parameters and mortality in a longitudinal, prospective, population-based cohort of 839 elderly subjects. Clinical data (including history of fractures and cardiovascular events) were assessed using a specific questionnaire. Laboratory exams, including serum 25OHD and PTH, were also performed. Bone mineral density (BMD) at the lumbar spine and hip were evaluated using DXA. All analyses were performed at baseline (2005 to 2007). Mortality was recorded during follow-up. Multivariate Cox proportional regression was used to compute hazard ratios for all-cause and cardiovascular mortality. Over a mean 4.06 +/- 1.07 years, there were 132 (15.7%) deaths. These individuals were compared to 707 subjects who were alive at the end of the coverage period for mortality data collection. In a multivariate Cox proportional hazards model, age (HR 1.32; 95% CI, 1.13 to 1.55; p=0.001, for each 5-year increase), male gender (HR 1.90; 95% CI, 1.30 to 2.79; p=0.001), recurrent falls (more than two in the previous year; HR 1.65; 95% CI, 1.06 to 2.56; p=0.026), diabetes mellitus (HR 2.17; 95% CI, 1.46 to 3.21; p<0.001), low physical activity score (HR 1.78; 95% CI, 1.14 to 2.79; p=0.011), prior cardiovascular event (HR 1.76; 95% CI, 1.18 to 2.63; p=0.006), total hip BMD (HR 1.41; 95% CI, 1.15 to 1.72; p=0.001, per each 1 SD decrease), and intact PTH (iPTH) (HR 1.06; 95% CI, 1.04 to 1.08; p<0.001, per each 10pg/mL increase) were independently associated with all-cause mortality. The subjects in the highest quartile of PTH (>49pg/mL) were at a higher risk of cardiovascular death (HR 3.09; 95% CI, 1.36 to 6.99; p=0.007) compared with the subjects in the lowest quartile (<26pg/mL). Low BMD and higher PTH were significantly associated with mortality in community-dwelling older adults. These findings support the notion that careful screening of these bone parameters might lead to better management of older patients and improve outcomes in this population. (c) 2016 American Society for Bone and Mineral Research. (AU)

FAPESP's process: 09/15346-4 - Incidence of vertebral fractures and non-vertebral clinical fractures in a population of individuals aged 65 or more
Grantee:Rosa Maria Rodrigues Pereira
Support Opportunities: Regular Research Grants
FAPESP's process: 03/09313-0 - Prevalence of osteoporosis, vertebral and non-vertebral fractures in a female population aged 65 or older in the Butantã area
Grantee:Rosa Maria Rodrigues Pereira
Support Opportunities: Regular Research Grants
FAPESP's process: 04/12694-8 - Incidence of dementia and cognitive decline in low-income elderly in São Paulo: a cohort study
Grantee:Isabela Judith Martins Bensenor
Support Opportunities: Regular Research Grants
FAPESP's process: 11/00411-5 - Incidence of vertebral fractures and non-vertebral clinical fractures in a population of individuals age 65 or more
Grantee:Diogo Souza Domiciano
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)