Colomeu, Talita Cristina
Gonzalez Schumacher, Nayara Simon
Stivanin-Silva, L. G.
Betim Cazarin, Cinthia Bau
Molina Meletti, Laura Maria
Romani Fernandes, Luis Gustavo
Prado, Marcelo Alexandre
Zollner, R. L.
Total Authors: 9
 Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, Lab Translat Immunol, Rua Vital Brasil 300, Cidade Univ Zeferino Vaz, BR-13083887 Campinas, SP - Brazil
 Agron Inst Campinas, Av Theodureto de Almeida Camargo 1500, BR-13012970 Campinas, SP - Brazil
 Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, Rua Alexandre Fleming 09, Campinas, SP - Brazil
Total Affiliations: 4
Web of Science Citations:
Passiflora alata Curtis (P. alata) leaves have anti-inflammatory properties; the present study aimed to investigate the anti-diabetogenic properties of P. alata aqueous leaf extract. HPLC analysis identified the phenolic compounds catechin, epicatechin and rutin. The aqueous extract was administered for 30 weeks to non-obese diabetic (NOD) mice presenting a decrease of 28.6% in diabetes incidence and the number of inflammatory cells in pancreatic islets, when compared with the control group (water). The P. alata group presented an antioxidant effect and decreased lipid peroxidation in the serum of NOD mice. Increased numbers of insulin-positive cells were also observed in the pancreatic islets of the treated group. The diabetic group exhibited higher levels in the glucose tolerance test and glycemic index, in comparison to the P. alata-treated group and non-diabetic control BALB/c mice. In addition, the P. alata extract reduced the percentage and the proliferation index of NOD mice lymphocytes submitted to in vitro dose/response mitogenic stimulation assays. These results suggest that the aqueous extract of P. alata has anti-inflammatory properties, contributing to the protection of beta cells in pancreatic islets in NOD mice, and presents potential for use a supporting approach to treat type I diabetes. (C) 2016 Elsevier B.V. All rights reserved. (AU)