Obstructive Sleep Apnea and Cardiovascular Events After Percutaneous Coronary Intervention

Author(s):Show less -

Lee, Chi-Hang ^[1] ; Sethi, Rishi ^[2] ; Li, Ruogu ^[3] ; Ho, Hee-Hwa ^[4] ; Hein, Thet ^[5] ; Jim, Man-Hong ^[6] ; Loo, Germaine ^[1] ; Koo, Chieh-Yang ^[1] ; Gao, Xiao-Fei ^[7] ; Chandra, Sharad ^[2] ; Yang, Xiao-Xiao ^[3] ; Furlan, Sofia F. ^[8] ; Ge, Zhen ^[7] ; Mundhekar, Ajeya ^[2] ; Zhang, Wei-Wei ^[3] ; Uchoa, Carlos Henrique G. ^[8] ; Kharwar, Rajiv Bharat ^[2] ; Chan, Po-Fun ^[1] ; Chen, Shao-Liang ^[7] ; Chan, Mark Y. ^[1] ; Richards, Arthur Mark ^[1] ; Tan, Huay-Cheem ^[1] ; Ong, Thun-How ^[9] ; Roldan, Glenn ^[10] ; Tai, Bee-Choo ^[11] ; Drager, Luciano F. ^[8] ; Zhang, Jun-Jie ^[7]

Affiliation:Show less -

^[1] Natl Univ Singapore, Ctr Heart, Dept Cardiol, 1E Kent Ridge Rd, NUHS Tower Block Level 9, Singapore 119228 - Singapore

^[2] King Georges Med Univ, Dept Cardiol, Lucknow, Uttar Pradesh - India

^[3] Shanghai Chest Hosp, Dept Cardiol, Shanghai - Peoples R China

^[4] Tan Tock Seng Hosp, Dept Cardiol, Singapore - Singapore

^[5] 1 1000 Bed Def Serv Gen Hosp, Mingaladon, Yangon - Myanmar

^[6] Grantham Hosp, Cardiac Med Unit, Hong Kong, Hong Kong - Peoples R China

^[7] Nanjing Med Univ, Nanjing Hosp 1, Dept Cardiol, Nanjing, Jiangsu - Peoples R China

^[8] Univ Sao Paulo, Sch Med, Hypertens Unit, Heart Inst InCor, BR-05508 Sao Paulo - Brazil

^[9] Singapore Gen Hosp, Dept Resp & Crit Care Med, Singapore - Singapore

^[10] Sleep Educ, Antioch, CA - USA

^[11] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 119228 - Singapore

• Document type: Journal article
• Source: Circulation; v. 133, n. 21, p. 2008-2017, MAY 24 2016.
• Web of Science Citations: 59

Abstract

Background There is a paucity of data from large cohort studies examining the prognostic significance of obstructive sleep apnea (OSA) in patients with coronary artery disease. We hypothesized that OSA predicts subsequent major adverse cardiac and cerebrovascular events (MACCEs) in patients undergoing percutaneous coronary intervention. Methods and Results The Sleep and Stent Study was a prospective, multicenter registry of patients successfully treated with percutaneous coronary intervention in 5 countries. Between December 2011 and April 2014, 1748 eligible patients were prospectively enrolled. The 1311 patients who completed a sleep study within 7 days of percutaneous coronary intervention formed the cohort for this analysis. Drug-eluting stents were used in 80.1% and bioresorbable vascular scaffolds in 6.3% of the patients, and OSA, defined as an apnea-hypopnea index of 15 events per hour, was found in 45.3%. MACCEs, a composite of cardiovascular mortality, nonfatal myocardial infarction, nonfatal stroke, and unplanned revascularization, occurred in 141 patients during the median follow-up of 1.9 years (interquartile range, 0.8 years). The crude incidence of an MACCEs was higher in the OSA than the non-OSA group (3-year estimate, 18.9% versus 14.0%; p=0.001). Multivariate Cox regression analysis indicated that OSA was a predictor of MACCEs, with an adjusted hazard ratio of 1.57 (95% confidence interval, 1.10-2.24; P=0.013), independently of age, sex, ethnicity, body mass index, diabetes mellitus, and hypertension. Conclusions OSA is independently associated with subsequent MACCEs in patients undergoing percutaneous coronary intervention. Evaluation of therapeutic approaches to mitigate OSA-associated risk is warranted. Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT01306526. (AU)

• FAPESP's process: 12/02953-2 - Impact of obstructive sleep apnea and sleep duration on the progression of cardiovascular diseases
• Grantee: Luciano Ferreira Drager
• Support Opportunities: Research Grants - Young Investigators Grants