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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Object recognition impairment and rescue by a dopamine D2 antagonist in hyperdopaminergic mice

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Author(s):
Franca, Arthur S. C. [1] ; Muratori, Larissa [2] ; Nascimento, George Carlos [3] ; Pereira, Catia Mendes [4] ; Ribeiro, Sidarta [1] ; Lobao-Soares, Bruno [5]
Total Authors: 6
Affiliation:
[1] Univ Fed Rio Grande do Norte, Inst Brain, BR-59056450 Natal, RN - Brazil
[2] Univ Fed Rio Grande do Norte, Dept Biochem, Natal, RN - Brazil
[3] Univ Fed Rio Grande do Norte, Med Engn Dept, Natal, RN - Brazil
[4] Edmond & Lily Safra Int Inst Neurosci Natal, Natal, RN - Brazil
[5] Univ Fed Rio Grande do Norte, Biophys & Pharmacol Dept, BR-59078970 Natal, RN - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Behavioural Brain Research; v. 308, p. 211-216, JUL 15 2016.
Web of Science Citations: 5
Abstract

Genetically-modified mice without the dopamine transporter (DAT) are hyperdopaminergic, and serve as models for studies of addiction, mania and hyperactive disorders. Here we investigated the capacity for object recognition in mildly hyperdopaminergic mice heterozygous for DAT (DAT +/-), with synaptic dopaminergic levels situated between those shown by DAT -/- homozygous and wild-type (WT) mice. We used a classical dopamine D2 antagonist, haloperidol, to modulate the levels of dopaminergic transmission in a dose-dependent manner, before or after exploring novel objects. In comparison with WT mice, DAT +/- mice showed a deficit in object recognition upon subsequent testing 24 h later. This deficit was compensated by a single 0.05 mg/kg haloperidol injection 30 min before training. In all mice, a 0.3 mg/kg haloperidol injected immediately after training impaired object recognition. The results indicate that a mild enhancement of dopaminergic levels can be detrimental to object recognition, and that this deficit can be rescued by a low dose of a D2 dopamine receptor antagonist. This suggests that novel object recognition is optimal at intermediate levels of D2 receptor activity. (C) 2016 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 13/07699-0 - Research, Innovation and Dissemination Center for Neuromathematics - NeuroMat
Grantee:Oswaldo Baffa Filho
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC