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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chemopreventive effects of pequi oil (Caryocar brasiliense Camb.) on preneoplastic lesions in a mouse model of hepatocarcinogenesis

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Author(s):
Palmeira, Simone M. [1] ; Silva, Paula R. P. [1] ; Ferrao, Juliana S. P. [1] ; Ladd, Aliny A. B. L. [1] ; Dagli, Maria L. Z. [1] ; Grisolia, Cesar K. [2] ; Hernandez-Blazquez, Francisco J. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Sao Paulo - Brazil
[2] Univ Brasilia, Inst Biol Sci, Brasilia, DF - Brazil
Total Affiliations: 2
Document type: Journal article
Source: European Journal of Cancer Prevention; v. 25, n. 4, p. 299-305, JUL 2016.
Web of Science Citations: 6
Abstract

Pequi (Caryocar brasiliense Camb.), a fruit from Brazil's central region, was evaluated for its chemopreventive effects on preneoplastic liver lesions induced by the carcinogen diethylnitrosamine (DEN) in mice. BALB/c mice, 14 days of age, received an intraperitoneal injection at 10 mu g/g of DEN. The mice received either of two doses of pequi oil (100 or 400mg/kg) daily from the age of 30 days and were killed at the age of 189 days. Stereological parameters, including the volume density (V-v) and the total volume (V-tot) of the lesions (preneoplastic and adenomas), were measured and the expression of cytokeratins CK8/18 was evaluated. The total volume of lesions and adenomas was reduced by 51% in the group treated with the carcinogen and 400mg/kg of pequi oil administered daily by an oral gavage for 25 consecutive weeks. In addition, some mice in this group did not develop lesions. Among the remaining preneoplastic lesions in this group, the number of remodelled profiles increased by 2.4-fold in the 400-mg pequi oil-treated mice relative to the 100-mg-treated mice. Our results show that pequi oil exerts a hepatoprotective effect against DEN-induced development of preneoplastic lesions and adenoma in mice and the potential for its use in the prevention of liver cancer. (AU)

FAPESP's process: 11/15415-6 - Evaluation of potential chemopreventive oil pequi (Caryocar brasiliense Camb.) by medium-term test
Grantee:Simone Morais Palmeira
Support Opportunities: Scholarships in Brazil - Master