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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The role of endogenous opioid peptides in the antinociceptive effect of 15-deoxy(Delta 12,14)-prostaglandin J(2) in the temporomandibular joint

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Author(s):
Macedo, C. G. [1] ; Napimoga, M. H. [2] ; Rocha-Neto, L. M. [1] ; Abdalla, H. B. [1] ; Clemente-Napimoga, J. T. [1]
Total Authors: 5
Affiliation:
[1] Univ Campinas UNICAMP, Piracicaba Dent Sch, Dept Physiol Sci, Lab Orofacial Pain, Av Limeira 901, BR-13414903 Piracicaba, SP - Brazil
[2] Rio Leopoldo Mand Inst & Res Ctr, Lab Immunol & Mol Biol, Rua Jose Rocha Junqueira 13, BR-13045755 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS; v. 110, p. 27-34, JUL 2016.
Web of Science Citations: 4
Abstract

We have previously demonstrated that peripheral administration of 15d-PGJ(2) in the Temporomandibular joint (TMJ) of rats can prevent nociceptor sensitization, mediated by peroxisome proliferator activated receptor-gamma (PPAR-gamma), and kappa- and delta- opioid receptors. However, the mechanism that underlies the signaling of PPAR-gamma (upon activation by 15d-PGJ(2)) to induce antinociception, and how the opioid receptors are activated via 15d-PGJ(2) are not fully understood. This study demonstrates that peripheral antinociceptive effect of 15d-PGJ(2) is mediated by PPAR-gamma expressed in the inflammatory cells of TMJ tissues. Once activated by 15d-PGJ(2), PPAR-gamma induces the release of beta-endorphin and dynorphin, which activates kappa- and delta-opioid receptors in primary sensory neurons to induce the antinociceptive effect. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 11/00683-5 - Evaluation of the peripheral effect of 15d-PGJ2 on rheumatoid arthritis-induced inflammatory response in the TMJ of rats
Grantee:Juliana Trindade Clemente Napimoga
Support Opportunities: Regular Research Grants