The role of endogenous opioid peptides in the antinociceptive effect of 15-deoxy(Delta 12,14)-prostaglandin J(2) in the temporomandibular joint

Author(s)

Macedo, C. G. ^[1] ; Napimoga, M. H. ^[2] ; Rocha-Neto, L. M. ^[1] ; Abdalla, H. B. ^[1] ; Clemente-Napimoga, J. T. ^[1]

Affiliation

^[1] Univ Campinas UNICAMP, Piracicaba Dent Sch, Dept Physiol Sci, Lab Orofacial Pain, Av Limeira 901, BR-13414903 Piracicaba, SP - Brazil

^[2] Rio Leopoldo Mand Inst & Res Ctr, Lab Immunol & Mol Biol, Rua Jose Rocha Junqueira 13, BR-13045755 Campinas, SP - Brazil

• Document type: Journal article
• Source: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS; v. 110, p. 27-34, JUL 2016.
• Web of Science Citations: 4

Abstract

We have previously demonstrated that peripheral administration of 15d-PGJ(2) in the Temporomandibular joint (TMJ) of rats can prevent nociceptor sensitization, mediated by peroxisome proliferator activated receptor-gamma (PPAR-gamma), and kappa- and delta- opioid receptors. However, the mechanism that underlies the signaling of PPAR-gamma (upon activation by 15d-PGJ(2)) to induce antinociception, and how the opioid receptors are activated via 15d-PGJ(2) are not fully understood. This study demonstrates that peripheral antinociceptive effect of 15d-PGJ(2) is mediated by PPAR-gamma expressed in the inflammatory cells of TMJ tissues. Once activated by 15d-PGJ(2), PPAR-gamma induces the release of beta-endorphin and dynorphin, which activates kappa- and delta-opioid receptors in primary sensory neurons to induce the antinociceptive effect. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 11/00683-5 - Evaluation of the peripheral effect of 15d-PGJ2 on rheumatoid arthritis-induced inflammatory response in the TMJ of rats
• Grantee: Juliana Trindade Clemente Napimoga
• Support Opportunities: Regular Research Grants