The role of free fatty acids in the inflammatory and cardiometabolic profile in adolescents with metabolic syndrome engaged in interdisciplinary therapy

Author(s):Show less -

Landi Masquio, Deborah Cristina ^[1] ; de Piano-Ganen, Aline ^[2] ; Oyama, Lila Missae ^{[1, 3]} ; da Silveira Campos, Raquel Munhoz ^[1] ; Santamarinaa, Aline Boveto ^[1] ; de Morais Honorato de Souza, Gabriel Inacio ^[1] ; Gomes, Aline Dal'Olio ^[4] ; Moreira, Renata Guimaraes ^[4] ; Corgosinho, Flavia Campos ^[1] ; Oller do Nascimento, Claudia Maria ^{[1, 3]} ; Tock, Lian ^[5] ; Tufik, Sergio ^[6] ; de Mello, Marco Tulio ^{[6, 1]} ; Damaso, Ana R. ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, UNIFESP, Programa Posgrad Nutr, Sao Paulo - Brazil

^[2] Ctr Univ Sao Camilo, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Lab Fisiol Nutr, UNIFESP, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Inst Biociencias, Dept Fisiol Geral, BR-05508 Sao Paulo - Brazil

^[5] Weight Sci, Sao Paulo - Brazil

^[6] Univ Fed Sao Paulo, Dept Psicobiol, UNIFESP, Sao Paulo - Brazil

• Document type: Journal article
• Source: JOURNAL OF NUTRITIONAL BIOCHEMISTRY; v. 33, p. 136-144, JUL 2016.
• Web of Science Citations: 9

Abstract

The purpose of the present study was to evaluate if interdisciplinary therapy can influence the cardiometabolic and serum free fatty acid profile. The second aim was to evaluate if there is an association between serum free fatty acids, inflammation and cardiometabolic biomarkers in obese adolescents with and without metabolic syndrome submitted to a long-term interdisciplinary therapy. The study involved 108 postpuberty obese adolescents, who were divided according to metabolic syndrome (MetS) diagnosis: MetS (n=32) and Non-MetS (n=76). The interdisciplinary therapy consisted of a 1-year period of nutrition, psychology, physical exercise and clinical support. After therapy, both groups improved metabolic, inflammatory (leptin, adiponectin, leptin/adiponectin ratio, adiponectin/leptin ratio and C-reactive protein) and cardiometabolic profile (PAI-1 and ICAM). Metabolic syndrome prevalence reduced from 28.70% to 12.96%. Both groups reduced myristic acid (C14:0) and increased docosahexaenoic acid (DHA, C22:6n3), heneicosapentaenoic acid (HPA, C21:5n3) and arachidonic acid (C20:4n6). After adjustment for metabolic syndrome and the number of metabolic syndrome parameters, multiple regression analysis showed that changes in VCAM and PAI-1 were negatively associated with changes in cis-linoleic acid (C18:2n6c). Additionally, changes in trans-linoleic acid (C18:2n6t) were also positively associated with these biomarkers. Moreover, leptin and leptin/adiponectin ratio were negatively associated with changes in docosapentaenoic acid (DPA, C22:5n3) and stearidonic acid (SDA, C18:4n3). Adiponectin/leptin ratio was positively associated with docosapentaenoic acid (DPA, C22:5n3). Changes in adiponectin were positively correlated with changes in omega 3, such as heneicosapentaenoic acid (HPA, C21:5n3) and docosapentaenoic acid (DPA, C22:5n3). Results support that interdisciplinary therapy can control inflammatory and cardiometabolic profile in obese adolescents. Moreover, serum fatty acids can be influenced by lifestyle changes and are able to modulate these biomarkers. (C) 2016 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 11/50414-0 - Influence of hyperleptinemia on inflammatory and atherogenic responses in obese adolescents
• Grantee: Ana Raimunda Dâmaso
• Support Opportunities: Regular Research Grants