| Full text | |
| Author(s): |
Borges, Cynthia M.
[1]
;
Papadimitriou, Alexandros
[1]
;
Duarte, Diego A.
[1]
;
de Faria, Jacqueline M. Lopes
[1]
;
de Faria, Jose B. Lopes
[1]
Total Authors: 5
|
| Affiliation: | [1] State Univ Campinas UNICAMP, Fac Med Sci FCM, Renal Pathophysiol Lab, Invest Diabet Complicat, Nephrol Unit, Campinas, SP - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 6, JUN 20 2016. |
| Web of Science Citations: | 21 |
| Abstract | |
Prior research has shown that in experimental diabetes mellitus, green tea reduces albuminuria by decreasing podocyte apoptosis through activation of the WNT pathway. We investigated the effect of green tea polyphenols (GTP) on residual albuminuria of diabetic subjects with nephropathy. We conducted a randomised, double-blind study in 42 diabetic subjects with a urinary albumin-creatinine ratio (UACR) > 30 mg/g, despite administration of the maximum recommended dose of renin-angiotensin (RAS) inhibition. Patients were randomly assigned to two equal groups to receive either GTP (containing 800 mg of epigallocatechin gallate, 17 with type 2 diabetes and 4 with type 1 diabetes) or placebo (21 with type 2 diabetes) for 12 weeks. Treatment with GTP reduced UACR by 41%, while the placebo group saw a 2% increase in UACR (p = 0.019). Podocyte apoptosis (p = 0.001) and in vitro albumin permeability (p < 0.001) were higher in immortalized human podocytes exposed to plasma from diabetic subjects compared to podocytes treated with plasma from normal individuals. In conclusion, GTP administration reduces albuminuria in diabetic patients receiving the maximum recommended dose of RAS. Reduction in podocyte apoptosis by activation of the WNT pathway may have contributed to this effect. (AU) | |
| FAPESP's process: | 08/57560-0 - Effects of green tea (Camellia sinensis), cocoa and nitric oxide donor on diabetic nephropathy and retinopathy: contribution of the reduction of oxidative stress and inflammation and elevation of nitric oxide |
| Grantee: | Jose Butori Lopes de Faria |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 14/22687-0 - Contribution of AMPK pathway to renal fibrosis and pathogenesis of diabetic nephropathy and retinopathy |
| Grantee: | Jose Butori Lopes de Faria |
| Support Opportunities: | Research Projects - Thematic Grants |