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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Verbascoside Inhibits Promastigote Growth and Arginase Activity of Leishmania amazonensis

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Author(s):
Maquiaveli, Claudia C. [1] ; Lucon-Junior, Joao F. [2] ; Brogi, Simone [3, 4] ; Campiani, Giuseppe [3, 4] ; Gemma, Sandra [3, 4] ; Vieira, Paulo C. [1] ; Silva, Edson R. [2]
Total Authors: 7
Affiliation:
[1] Univ Fed Sao Carlos, Dept Chem, Rod Washington Luis, Km 235, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Dept Vet Med, Ave Duque Caxias Norte 225, BR-13635900 Pirassununga, SP - Brazil
[3] Univ Siena, European Res Ctr Drug Discovery & Dev NatSynDrugs, Via Aldo Moro 2, I-53100 Siena - Italy
[4] Univ Siena, Dept Biotechnol Chem & Pharm, Via Aldo Moro 2, I-53100 Siena - Italy
Total Affiliations: 4
Document type: Journal article
Source: Journal of Natural Products; v. 79, n. 5, p. 1459-1463, MAY 2016.
Web of Science Citations: 13
Abstract

Verbascoside (1) is a phenylethanoid glycoside that has antileishmanial activity against Leishmania infantum and Leishmania donovani. In this study, we verified the activity of 1 on Leishmania amazonensis and arginase inhibition. Compound 1 showed an EC50 of 19 mu M against L. amazonensis promastigotes and is a competitive arginase inhibitor (K-i = 0.7 mu M). Docking studies were performed to assess the interaction of 1 with arginase at the molecular level. Arginase is an enzyme of the polyamine biosynthesis pathway that is important to parasite infectivity, and the results of our study suggest that 1 could be useful to develop new approaches for treating leishmaniasis. (AU)

FAPESP's process: 14/18642-1 - Arginase enzyme as a target to development of new prototype compound against Leishmania
Grantee:Edson Roberto da Silva
Support Opportunities: Regular Research Grants