| Full text | |
| Author(s): |
Anne E.D. Arraes
[1]
;
Alexandre W.S. de Souza
[2]
;
Henrique A. Mariz
[3]
;
Neusa P. Silva
[4]
;
Ivone C.G. Torres
[5]
;
Paula N.V. Pinto
[6]
;
Eduardo N.P. Lima
[7]
;
Emilia I. Sato
[8]
Total Authors: 8
|
| Affiliation: | [1] Universidade Federal de São Paulo. Escola Paulista de Medicina. Rheumatology Division - Brasil
[2] Universidade Federal de São Paulo. Escola Paulista de Medicina. Rheumatology Division - Brasil
[3] Universidade Federal de São Paulo. Escola Paulista de Medicina. Rheumatology Division - Brasil
[4] Universidade Federal de São Paulo. Escola Paulista de Medicina. Rheumatology Division - Brasil
[5] Hospital A.C. Camargo. Radiology Division - Brasil
[6] Hospital A.C. Camargo. Radiology Division - Brasil
[7] Hospital A.C. Camargo. Radiology Division - Brasil
[8] Universidade Federal de São Paulo. Escola Paulista de Medicina. Rheumatology Division - Brasil
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | REVISTA BRASILEIRA DE REUMATOLOGIA; v. 56, n. 4, p. 299-308, 2016-08-00. |
| Abstract | |
ABSTRACT Objective: To evaluate 18F-fluorodeoxyglucose (18F-FDG) uptake on positron emission tomography–computed tomography (PET–CT) and serum levels of different cytokines and matrix metalloproteinases (MMPs) in patients with Takayasu arteritis (TA) and associations with disease activity. Methods: Serum levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-2, IL-6, IL-8, IL-12, IL-18, MMP-3 and MMP-9 were measured in 36 TA patients and 36 controls. Maximum standard uptake value (SUVmax) of 18F-FDG in arterial walls was determined by PET–CT scans. TA patients were classified as active disease, inactive disease and possible active disease. Results: Serum IL-6 and MMP-3 levels were higher in TA patients than in controls (p < 0.001). Serum IL-6 was higher in patients with active disease and in patients with possible active disease than in inactive disease (p < 0.0001). Patients with active disease had higher serum TNFα levels than patients with inactive disease (p = 0.049) while patients with possible active disease presented higher IL-18 levels than patients with inactive disease (p = 0.046). Patients with active disease had higher SUVmax values than those with inactive disease (p = 0.042). By receiver operating characteristic (ROC) curve SUVmax was predictive of active disease in TA and values ≥1.3 were associated with disease activity (p = 0.039). Serum TNF-α levels were higher in patients with SUVmax ≥ 1.3 than <1.3 (p = 0.045) and controls (p = 0.012). Serum IL-6 levels were higher in patients with SUVmax ≥ 1.3 than in controls (p < 0.001). No differences regarding other biomarkers were found between TA patients and controls. Conclusions: Higher serum IL-6 and TNFα levels as well as higher 18F-FDG uptake in arterial wall are associated with active TA. (AU) | |