| Full text | |
| Author(s): |
Louzada Strufaldi, Maria Wany
;
Suano de Souza, Fabiola Isabel
;
Puccini, Rosana Fiorini
;
Pinho Franco, Maria do Carmo
Total Authors: 4
|
| Document type: | Journal article |
| Source: | Revista da Associação Médica Brasileira; v. 62, n. 4, p. 347-352, JUL 2016. |
| Web of Science Citations: | 1 |
| Abstract | |
Summary Objective: To describe the values of non-HDL cholesterol (NHDL-c) and the frequency of a family history of early cardiovascular disease (family HCVD) in healthy prepubescent children. Analyze the association between NHDL-c and family HCVD, and possible associations with other risk factors for cardiovascular disease (CVD). Method: Cross-sectional study including 269 prepubescent (aged 6-10 years) schoolchildren with a normal body mass index (+1SD<BMI>-2SD). Data collected: Family HCVD; weight and height, waist circumference and systemic blood pressure; lipid profile (total cholesterol TC, HDL-c, triglycerides and LDL-c), NHDL-c calculation (CT-HDL-c, cut-off = 145 mg/dL) and insulin resistance (HOMA-IR). Results: High levels were found for NHDL-c in 10 (3.7%) of these schoolchildren, and family early HCVD was found in 46 (17.1%) of them. There was a weak association between family HCVD and NHDL-c (Cramer’s-V-test = 0.120; p=0.050). Among the children with NHDL-c≥145 mg/dL, 4 (40%) have family HCVD. The presence of family HCVD was not associated with the variables being studied. The variables independently associated with NHDL-c ≥ 145 mg/dL were: HOMA-IR (OR=1.7; 95CI 1.1-2.6) and diastolic blood pressure (OR=1.1; 95CI 1.02-1.2). Conclusion: NHDL-c values were associated with blood pressure and insulin resistance. Family HCVD was not associated with other classic risk factors for CVD, even though the frequency found was five times higher than that of high NHDL-c. (AU) | |
| FAPESP's process: | 07/58044-2 - Birth weight and cardiovascular diseases: characterization of risk and genetic factors interrelation by identifying genomic imprinting mechanisms as well as genetic polymorphisms in homocysteine and eNOS pathways |
| Grantee: | Maria Do Carmo Pinho Franco |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 08/58963-0 - Birth weight, adipocytokines and factors associated with risk of cardiovascular diseases in children |
| Grantee: | Maria Wany Louzada Strufaldi |
| Support Opportunities: | Regular Research Grants |