Lithium Distinctly Modulates the Secretion of Pro- and Anti-Inflammatory Interleukins in Co-Cultures of Neurons and Glial Cells at Therapeutic and Sub-Therapeutic Concentrations

Author(s)

De-Paula, Vanessa J. ; Kerr, Daniel S. ; Scola, Gustavo ; Gattaz, Wagner F. ; Forlenza, Orestes V.

• Document type: Journal article
• Source: Current Alzheimer Research; v. 13, n. 8, p. 848-852, 2016.
• Web of Science Citations: 6

Abstract

Lithium is associated with various effects on immune functions, some of which are still poorly understood. The roles of many cytokines have been characterized in a variety of neurodevelopmental processes including neurogenesis, neuronal and glial cell migration, proliferation, differentiation, synaptic maturation and synaptic pruning. This work aims to evaluate the effects of different doses of lithium (0.02; 0.2 and 2mM) on the secretion of cytokines in co-cultures of cortical and hippocampal neurons with glial cells. Our results indicate that chronic treatment with lithium chloride at sub-therapeutic concentrations are able to modify the secretion of pro-and anti-inflammatory interleukins in co-cultures of cortical and hippocampal neurons with glial cells. (AU)

• FAPESP's process: 11/19892-3 - Effects of lithium on the expression and activity of the enzymes Phospholipase A2 and glycogen synthase kinase 3B and its relation to the phosphorylation state of Tau protein
• Grantee: Vanessa de Jesus Rodrigues de Paula
• Support type: Scholarships in Brazil - Doctorate
• FAPESP's process: 13/01352-8 - Lithium effect on micro RNA regulation of gene expression on an Alzheimer's Disease model by beta-amyloid induced neurotoxicity in neuronal primary cell culture
• Grantee: Daniel Shikanai Kerr
• Support type: Regular Research Grants
• FAPESP's process: 02/13633-7 - Phospholipid metabolism in neuropsychiatric disorders
• Grantee: Wagner Farid Gattaz
• Support type: Research Projects - Thematic Grants