| Full text | |
| Author(s): |
Pavani, Christiane
;
Francisco, Claudia M. L.
;
Gobo, Nicholas R. S.
;
de Oliveira, Kleber T.
;
Baptista, Mauricio S.
Total Authors: 5
|
| Document type: | Journal article |
| Source: | NEW JOURNAL OF CHEMISTRY; v. 40, n. 11, p. 9666-9671, 2016. |
| Web of Science Citations: | 8 |
| Abstract | |
A phthalocyanine-ALA conjugate showed an improved photoinduced cell killing efficiency due to the combined action of the phthalocyanine core and protoporphyrin IX, which was biosynthesised intracellularly by using released ALA as a substrate. The intracellular presence of two photosensitisers and their joint excitation induced a synergistic efficiency for cell killing. The construction of photosensitisers that release intracellular ALA holds great potential for the development of more efficient PDT photosensitisers. (AU) | |
| FAPESP's process: | 15/21110-4 - Exploiting Photocatalyzed Reactions Under Continuous Flow Conditions by using Porphyrinoid Systems: (C-FlowPhotoChem) |
| Grantee: | Kleber Thiago de Oliveira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/07276-1 - CEPOF - Optics and Photonic Research Center |
| Grantee: | Vanderlei Salvador Bagnato |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 12/50680-5 - Photosensitization in life sciences |
| Grantee: | Mauricio da Silva Baptista |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 12/24092-9 - About the synthesis of Naphthalocyanine derivatives: Strategies Involving Organometallic Couplings and Methane[10]annulenes |
| Grantee: | Nicholas Roberto da Silva Gobo |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 13/07937-8 - Redoxome - Redox Processes in Biomedicine |
| Grantee: | Ohara Augusto |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 09/01524-8 - Photodynamic Activity of ALA-funcionalizated Phthalocyanines |
| Grantee: | Christiane Pavani |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |