Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Improved photodynamic activity of a dual phthalocyanine-ALA photosensitiser

Full text
Author(s):
Pavani, Christiane ; Francisco, Claudia M. L. ; Gobo, Nicholas R. S. ; de Oliveira, Kleber T. ; Baptista, Mauricio S.
Total Authors: 5
Document type: Journal article
Source: NEW JOURNAL OF CHEMISTRY; v. 40, n. 11, p. 9666-9671, 2016.
Web of Science Citations: 8
Abstract

A phthalocyanine-ALA conjugate showed an improved photoinduced cell killing efficiency due to the combined action of the phthalocyanine core and protoporphyrin IX, which was biosynthesised intracellularly by using released ALA as a substrate. The intracellular presence of two photosensitisers and their joint excitation induced a synergistic efficiency for cell killing. The construction of photosensitisers that release intracellular ALA holds great potential for the development of more efficient PDT photosensitisers. (AU)

FAPESP's process: 15/21110-4 - Exploiting Photocatalyzed Reactions Under Continuous Flow Conditions by using Porphyrinoid Systems: (C-FlowPhotoChem)
Grantee:Kleber Thiago de Oliveira
Support Opportunities: Regular Research Grants
FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
Grantee:Vanderlei Salvador Bagnato
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 12/50680-5 - Photosensitization in life sciences
Grantee:Mauricio da Silva Baptista
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 12/24092-9 - About the synthesis of Naphthalocyanine derivatives: Strategies Involving Organometallic Couplings and Methane[10]annulenes
Grantee:Nicholas Roberto da Silva Gobo
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
Grantee:Ohara Augusto
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 09/01524-8 - Photodynamic Activity of ALA-funcionalizated Phthalocyanines
Grantee:Christiane Pavani
Support Opportunities: Scholarships in Brazil - Post-Doctorate