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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antiplasmodial activity of alkyl-substituted 1,2-dioxetanes against Plasmodium falciparum

Full text
Author(s):
Silva, Adriana F. ; Oliveira, Jr., Vani X. ; Silva, Leandro S. ; Pinheiro, Ana A. S. ; Ciscato, Luiz F. M. L.
Total Authors: 5
Document type: Journal article
Source: Bioorganic & Medicinal Chemistry Letters; v. 26, n. 20, p. 5007-5008, OCT 15 2016.
Web of Science Citations: 1
Abstract

This article reports the in vitro antiplasmodial activity of two endoperoxides of the class 1,2-dioxetanes against Plasmodium falciparum: bis(adamantyl)-1,2-dioxetane and 3,3,4,4-tetramethyl-1,2-dioxetane. The results reveal that bis(adamantyl)-1,2-dioxetane displays substantial antiplasmodial activity, at least two orders of magnitude higher than that of artemisinin, while 3,3,4,4-tetramethyl-1,2-dioxetane is less active. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 12/02428-5 - Cyclic organic peroxides: synthesis and mechanism of reduction
Grantee:Luiz Francisco Monteiro Leite Ciscato
Support Opportunities: Regular Research Grants
FAPESP's process: 11/10823-9 - Antimalarial compounds derivative from angiotensin II
Grantee:Vani Xavier de Oliveira Junior
Support Opportunities: Regular Research Grants