| Full text | |
| Author(s): |
Abigail Mendes Araujo, Maria Jose
;
Gimenes Bosco, Sandra de Moraes
;
Sforcin, Jose Mauricio
Total Authors: 3
|
| Document type: | Journal article |
| Source: | Brazilian Journal of Microbiology; v. 47, n. 4, p. 863-869, OCT-DEC 2016. |
| Web of Science Citations: | 6 |
| Abstract | |
Abstract Propolis and geopropolis are resinous products of bees showing antimicrobial effects. There is no data concerning their action against Pythium insidiosum - the causative agent of pythiosis, a pyogranulomatous disease of the subcutaneous tissue that affects mostly horses, dogs and humans. Fragments of 15 isolates of P. insidiodum were incubated with propolis and geopropolis extracts and evaluated for up to seven days to detect the minimal fungicidal concentration (MFC). Propolis inhibited three isolates at 1.0 mg mL-1 after 24 h and all other isolates at 3.4 mg mL-1. Geopropolis led to more variable results, exerting predominantly a fungistatic action than a fungicidal one. Propolis was more efficient than geopropolis in inhibiting P. insidiosum since lower concentrations led to no growth after 24 h. This effect may be due to propolis chemical composition, which has more active compounds than geopropolis. Propolis seemed to be a good candidate for in vivo studies, since treatment with conventional antifungal compounds is difficult in most of the cases, requiring extensive surgical debridement. (AU) | |
| FAPESP's process: | 10/01028-8 - GEOPROPOLIS FROM Melipona fasciculata Smith: CYTOTOXIC, IMMUNOMODULATORY, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES |
| Grantee: | José Maurício Sforcin |
| Support Opportunities: | Regular Research Grants |