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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Aging Effects on Whole-Brain Functional Connectivity in Adults Free of Cognitive and Psychiatric Disorders

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Ferreira, Luiz Kobuti ; Brocanello Regina, Ana Carolina ; Kovacevic, Natasa ; Morais Martin, Maria da Graca ; Santos, Pedro Paim ; Carneiro, Camila de Godoi ; Kerr, Daniel Shikanai ; Amaro, Jr., Edson ; McIntosh, Anthony Randal ; Busatto, Geraldo F.
Total Authors: 10
Document type: Journal article
Source: CEREBRAL CORTEX; v. 26, n. 9, p. 3851-3865, SEP 2016.
Web of Science Citations: 33

Aging is associated with decreased resting-state functional connectivity (RSFC) within the default mode network (DMN), but most functional imaging studies have restricted the analysis to specific brain regions or networks, a strategy not appropriate to describe system-wide changes. Moreover, few investigations have employed operational psychiatric interviewing procedures to select participants; this is an important limitation since mental disorders are prevalent and underdiagnosed and can be associated with RSFC abnormalities. In this study, resting-state fMRI was acquired from 59 adults free of cognitive and psychiatric disorders according to standardized criteria and based on extensive neuropsychological and clinical assessments. We tested for associations between age and whole-brain RSFC using Partial Least Squares, a multivariate technique. We found that normal aging is not only characterized by decreased RSFC within the DMN but also by ubiquitous increases in internetwork positive correlations and focal internetwork losses of anticorrelations (involving mainly connections between the DMN and the attentional networks). Our results reinforce the notion that the aging brain undergoes a dedifferentiation processes with loss of functional diversity. These findings advance the characterization of healthy aging effects on RSFC and highlight the importance of adopting a broad, system-wide perspective to analyze brain connectivity. (AU)

FAPESP's process: 10/17083-8 - Brain function during autobiographical memory recovery in elderly subjects: a functional magnetic resonance imaging study
Grantee:Luiz Roberto Kobuti Ferreira
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 12/11898-5 - Partial least squares method in the analysis of resting-state functional magnetic resonance: study of the aging brain and autobiographical memory
Grantee:Luiz Roberto Kobuti Ferreira
Support type: Scholarships abroad - Research Internship - Doctorate (Direct)
FAPESP's process: 11/00475-3 - Retrieval of autobiographical memory and the aging brain: a study using functional magnetic resonance
Grantee:Geraldo Busatto Filho
Support type: Regular Research Grants
FAPESP's process: 12/50329-6 - Translational neuroscience of Alzheimer's disease: preclinical and clinical studies of b-amyloid peptide and other biomarkers
Grantee:Geraldo Busatto Filho
Support type: Research Projects - Thematic Grants