Crotapotin induced modification of T lymphocyte proliferative response through interference with PGE(2) synthesis

Garcia, Flavia; Toyama, Marcos H.; Castro, Fabiano R.; Proença, Patrícia L.; Marangoni, Sergio; Santos, Leonilda M. B.

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Crotapotin induced modification of T lymphocyte proliferative response through interference with PGE(2) synthesis

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Author(s):	Garcia, Flavia ; Toyama, Marcos H. ; Castro, Fabiano R. ; Proença, Patrícia L. ; Marangoni, Sergio ; Santos, Leonilda M. B. Total Authors: 6
Document type:	Journal article
Source:	Toxicon; v. 42, n. 4, p. 433-437, Sept. 2003.
Field of knowledge:	Biological Sciences - Immunology
Abstract
The immunosuppressive property has been demonstrated for the venom of the Crotalus durissus terrificus. Using a simple, novel method for obtaining crotapotin and phospholipase A2 isoforms from venom, it was possible to demonstrate that the addition of crotapotin to cultures of isolated lymphocytes resulted in a significant inhibition of the cellular proliferative response to Concanavalin A. This reduction in blastogenic response of lymphocytes is accompanied by a significant increase in the production of PGE2 by macrophages. This effect on the innate immune response suggests that this compound may modify the subsequent adaptative immune response. (AU)

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