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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Respiratory and autonomic dysfunction in congenital central hypoventilation syndrome

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Moreira, Thiago S. ; Takakura, Ana C. ; Czeisler, Catherine ; Otero, Jose J.
Total Authors: 4
Document type: Review article
Source: Journal of Neurophysiology; v. 116, n. 2, p. 742-752, AUG 2016.
Web of Science Citations: 9

The developmental lineage of the PHOX2B-expressing neurons in the retrotrapezoid nucleus (RTN) has been extensively studied. These cells are thought to function as central respiratory chemoreceptors, i.e., the mechanism by which brain P-CO2 regulates breathing. The molecular and cellular basis of central respiratory chemoreception is based on the detection of CO2 via intrinsic proton receptors (TASK-2, GPR4) as well as synaptic input from peripheral chemoreceptors and other brain regions. Murine models of congenital central hypoventilation syndrome designed with PHOX2B mutations have suggested RTN neuron agenesis. In this review, we examine, through human and experimental animal models, how a restricted number of neurons that express the transcription factor PHOX2B play a crucial role in the control of breathing and autonomic regulation. (AU)

FAPESP's process: 13/10573-8 - Ventral surface chemoreceptor neuronal mechanisms
Grantee:Thiago dos Santos Moreira
Support type: Regular Research Grants
FAPESP's process: 09/54888-7 - Neural mechanisms involved on chemoreception
Grantee:Eduardo Colombari
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/22406-1 - Respiratory anatomofunctional changes observed in an experimental model of Parkinson Disease
Grantee:Ana Carolina Thomaz Takakura
Support type: Regular Research Grants