| Full text | |
| Author(s): |
Moreira, Thiago S.
;
Takakura, Ana C.
;
Czeisler, Catherine
;
Otero, Jose J.
Total Authors: 4
|
| Document type: | Review article |
| Source: | Journal of Neurophysiology; v. 116, n. 2, p. 742-752, AUG 2016. |
| Web of Science Citations: | 9 |
| Abstract | |
The developmental lineage of the PHOX2B-expressing neurons in the retrotrapezoid nucleus (RTN) has been extensively studied. These cells are thought to function as central respiratory chemoreceptors, i.e., the mechanism by which brain P-CO2 regulates breathing. The molecular and cellular basis of central respiratory chemoreception is based on the detection of CO2 via intrinsic proton receptors (TASK-2, GPR4) as well as synaptic input from peripheral chemoreceptors and other brain regions. Murine models of congenital central hypoventilation syndrome designed with PHOX2B mutations have suggested RTN neuron agenesis. In this review, we examine, through human and experimental animal models, how a restricted number of neurons that express the transcription factor PHOX2B play a crucial role in the control of breathing and autonomic regulation. (AU) | |
| FAPESP's process: | 13/10573-8 - Ventral surface chemoreceptor neuronal mechanisms |
| Grantee: | Thiago dos Santos Moreira |
| Support type: | Regular Research Grants |
| FAPESP's process: | 09/54888-7 - Neural mechanisms involved on chemoreception |
| Grantee: | Eduardo Colombari |
| Support type: | Research Projects - Thematic Grants |
| FAPESP's process: | 14/22406-1 - Respiratory anatomofunctional changes observed in an experimental model of Parkinson Disease |
| Grantee: | Ana Carolina Thomaz Takakura |
| Support type: | Regular Research Grants |