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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A pilot randomized controlled trial of the Occupational Goal Intervention method for the improvement of executive functioning in patients with treatment-resistant schizophrenia

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Author(s):
Vizzotto, Adriana D. B. ; Celestino, Diego L. ; Buchain, Patricia C. ; Oliveira, Alexandra M. ; Oliveira, Grata M. R. ; Di Sarno, Elaine S. ; Napolitano, Isabel C. ; Elkis, Helio
Total Authors: 8
Document type: Journal article
Source: PSYCHIATRY RESEARCH; v. 245, p. 148-156, NOV 30 2016.
Web of Science Citations: 3
Abstract

Schizophrenia is a chronic disabling mental disorder that involves impairments in several cognitive domains, especially in executive functions (EF), as well as impairments in functional performance. This is particularly true in patients with Treatment-Resistant Schizophrenia (TRS). The aim of this study was to test the efficacy of the Occupational Goal Intervention (OGI) method for the improvement of EF in patients with TRS. In this randomized, controlled, single-blind pilot study, 25 TRS patients were randomly assigned to attend 30 sessions of either OGI or craft activities (control) over a 15-week period and evaluated by the Behavioural Assessment of the Dysexecutive Syndrome (BADS) as the primary outcome and the Direct Assessment of Functional Status (DAFS-BR) as well as the Independent Living Skills Survey (ILSS-BR) as secondary outcomes, all adapted for the Brazilian population. The Positive and Negative Syndrome Scale (PANSS) was used for monitoring symptom severity. Results showed significant statistical differences, favoring the OGI group in terms of improvement on the BADS, both in subtests (Action Program and Key Search) and the total score. Improvements in EFs were observed by families in various dimensions as measured by different subtests of the ILSS-BR inventory. The OGI group showed no significant results in secondary outcomes (DAFS-BR) except in terms of improvement of communication skills. Although preliminary, our results indicate that the OGI method is efficacious and effective for patients with TRS. (C) 2016 Elsevier Ireland Ltd. All rights reserved. (AU)

FAPESP's process: 12/01382-1 - Randomized and controlled trial to evaluate efficacy of occupational therapy in the rehabilitation of executive functions in patients with schizophrenia resistant
Grantee:Helio Elkis
Support Opportunities: Regular Research Grants