Cobalt-catalyzed oxidative cyclization of gem-disubstituted conjugated alkenols

Alves, Tania M. F.; Costa, Mateus O.; Bispo, Beatriz A. D.; Pedrosa, Fabiana L.; Ferreira, Marco A. B.

Advanced search

Search - Use quotation marks to get a more specific result

Index

Field of knowledge

Start date

Betweenand

(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cobalt-catalyzed oxidative cyclization of gem-disubstituted conjugated alkenols

Full text
Author(s):	Alves, Tania M. F. ; Costa, Mateus O. ; Bispo, Beatriz A. D. ; Pedrosa, Fabiana L. ; Ferreira, Marco A. B. Total Authors: 5
Document type:	Journal article
Source:	Tetrahedron Letters; v. 57, n. 30, p. 3334-3338, JUL 27 2016.
Web of Science Citations:	3
Abstract
Aryl gem-disubstituted conjugated alkenols underwent oxidative cyclization affording 2,5,5-trisubstituted tetrahydrofurans in reasonable yields and good diastereoselectivities using the reductive termination variation of the Mukaiyama aerobic oxidative reaction. Under oxidative termination, the same alkenols produced diols and ketonic by-products via the double hydration and beta-scission competing pathways. Furthermore, the differences in alkenol reactivity under the reductive and oxidative termination conditions were investigated. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process:	13/02311-3 - New approaches in asymmetric synthesis of tetrahydrofuran and tetrahydropyran-derivatives with potential application in the preparation of bioactive molecules
Grantee:	Marco Antonio Barbosa Ferreira
Support Opportunities:	Regular Research Grants

Short URL