Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Fluoride affects bone repair differently in mice models with distinct bone densities

Full text
Author(s):
Herrera, Paula Kennerly ; Zambolin, Andressa Pelissari ; Fernandes, Mileni da Silva ; Cestari, Tania Mary ; Iano, Flavia Godoy ; Zambuzzi, Willian Fernando ; Rabelo Buzalaf, Marilia Afonso ; de Oliveira, Rodrigo Cardoso
Total Authors: 8
Document type: Journal article
Source: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY; v. 39, p. 129-134, 2017.
Web of Science Citations: 2
Abstract

We grouped mice {[}strains: C57BL/6J (n = 32) and C3H/HeJ (n = 32)] to address the influence of bone density on fluoride's (F's) biological effects. These animals received low-fluoride food and water containing 0 (control group) or 50 ppm of F for up to 28 days. The upper left central incisor was extracted, and the left maxilla was collected at 7, 14, 21, and 28 days for histological and histomorphometric analysis to estimate bone neoformation. Our results showed bone neoformation in all of the evaluated groups, with the presence of bone islets invading the center of the alveoli when replacing the existing connective tissue. Curiously, this biological phenomenon was more evident in the C57BL/6J strain. The histomorphometric analysis confirmed the histological findings in relation to the amount of new bone tissue and showed a decrease in C3H/HeJ mice (control group). Altogether, our results showed differential effects of fluoride bone metabolism, confirming a genetic component in susceptibility to the effects of fluoride. (C) 2016 Elsevier GmbH. All rights reserved. (AU)

FAPESP's process: 11/01425-0 - Effect of flouride on bone healing in the alveoli of mice with different bone densities: morphometric and zymography analysis
Grantee:Rodrigo Cardoso de Oliveira
Support Opportunities: Regular Research Grants
FAPESP's process: 12/02229-2 - Histological analysis of the effect of fluoride on bone repair in mice dental alveoli with different bone densities
Grantee:Paula Kennerly Herrera
Support Opportunities: Scholarships in Brazil - Scientific Initiation