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Histological analysis of the effect of fluoride on bone repair in mice dental alveoli with different bone densities.

Grant number: 12/02229-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2012
Effective date (End): December 31, 2013
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal researcher:Rodrigo Cardoso de Oliveira
Grantee:Paula Kennerly Herrera
Home Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil

Abstract

Between various therapeutic proposals for the osteoporosis treatment, the administration of high doses of fluoride is an alternative that still has controversies in literature. Fluoride is highlighted by influencing the activity of osteoblasts, which are responsible for mediating the synthesis of the bone. But, the mechanism of action of fluoride on bone cells (osteoblasts, osteocytes and osteoclasts) is not well understood. This way, this study aims to evaluate the alveolar bone repair in rats under the effect of fluoride administered in the water. This work will use four groups of strains C57BL/6J mice (total of 32) and C3H/HeJ (total of 32) of 60 days, which will receive deionized water and water with 50 ppm of fluoride. The surgical procedures will be made by extracting the upper left incisor and then the animals will be euthanized in the 7, 14, 21 and 28 days. There will be histological analysis (hematoxylin eosin staining) by light microscopy. The statistical analysis will be done through the statistical test one-way ANOVA complemented by Tukey's test, Kruskal-Wallis test complemented by Dunn and will be at the "t" test, according to his statement (p <0.05).

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HERRERA, PAULA KENNERLY; ZAMBOLIN, ANDRESSA PELISSARI; FERNANDES, MILENI DA SILVA; CESTARI, TANIA MARY; IANO, FLAVIA GODOY; ZAMBUZZI, WILLIAN FERNANDO; RABELO BUZALAF, MARILIA AFONSO; DE OLIVEIRA, RODRIGO CARDOSO. Fluoride affects bone repair differently in mice models with distinct bone densities. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, v. 39, p. 129-134, 2017. Web of Science Citations: 2.

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