The role of CCR5 in Chagas disease - a systematic review

Author(s)

de Oliveira, Amanda P. ; Ayo, Christiane M. ; Bestetti, Reinaldo B. ; Brandao de Mattos, Cinara C. ; Cavasini, Carlos E. ; de Mattos, Luiz C.

• Document type: Review article
• Source: INFECTION GENETICS AND EVOLUTION; v. 45, p. 132-137, NOV 2016.
• Web of Science Citations: 7

Abstract

Chagas disease is an infection caused by the protozoan Trypanosoma cruzi. The clinical manifestations result from the chronic forms of the disease: indeterminate, cardiac, digestive or mixed. The pathogenesis of this disease is related to the genetic variability of both the parasite and the host with polymorphisms of genes involved in immune response possibly being involved in the variable clinical course. Cytokines play a key role in regulating immune response, in particular chemokines exert a crucial role in the control of leukocyte migration during the host's response to infectious processes. Furthermore, inflammatory cytokines and chemokines have been implicated in the generation of inflammatory infiltrates and tissue damage. The involvement of the CC Chemokine Receptor 5 (CCR5) in leukocyte migration to sites of inflammation has been elucidated and this receptor has been investigated in Chagas disease. Here we review the role of CCR5 in T. cruzi infection as well as its importance in the pathogenesis of the Chagas disease. (C) 2016 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 13/06580-9 - KIR genes, their HLA ligands and MICA gene polymorphism in ocular toxoplasmosis and in digestive form of Chagas disease
• Grantee: Christiane Maria Ayo
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 11/08075-4 - Immunogenetic markers related to Chagas disease
• Grantee: Luiz Carlos de Mattos
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/05580-2 - Immunogenetics markers in Chagas disease
• Grantee: Cássia Rubia Bernardo
• Support Opportunities: Scholarships in Brazil - Master