Preliminary Results of Non-Surgical Periodontal Treatment in Patients With Breast Cancer Undergoing Chemotherapy

Author(s)

Vargas-Villafuerte, Kelly R. ; Dantas, Felipe T. ; Messora, Michel R. ; Novaes, Jr., Arthur B. ; Grisi, Marcio F. ; Taba, Jr., Mario ; Souza, Sergio L. ; Candido dos Reis, Francisco J. ; Carrara, Helio H. A. ; Palioto, Daniela B.

• Document type: Journal article
• Source: Journal of Periodontology; v. 87, n. 11, p. 1268-1277, NOV 2016.
• Web of Science Citations: 2

Abstract

Background: Although priority is often given to treat the cancer itself, focus should also be directed to prevention and improvement of oral complications that may occur as a result of cancer and/or its treatment. This study compares periodontal treatment results in healthy patients and patients with breast cancer undergoing chemotherapy by monitoring clinical conditions and C-reactive-protein (CRP) levels. Methods: Thirty-five participants were allocated to one of two groups: patients with periodontitis (P) (n = 18) and patients with breast cancer and periodontitis (CAN/P) (n = 17). The following clinical parameters were assessed at baseline and 45, 90, and 180 days after non-surgical periodontal treatment (NSPT): 1) probing depth (PD); 2) clinical attachment level (CAL); 3) plaque index (PI); 4) gingival index (GI); 5) CRP; and 6) complete blood count. Clinical parameters and CRP levels were statistically analyzed. Results: P and CAN/P groups presented a statistically significant decrease in PD after NSPT at 45, 90, and 180 days compared with baseline (P < 0.05). There was a CAL gain in the P group and a significant reduction in PI and GI at 45, 90, and 180 days for both groups (P < 0.05). At 180 days after NSPT treatment, the CAN/P group showed a higher number of residual pockets (P < 0.05) compared with the P group (46.48 +/- 26.80 and 7.58 +/- 7.40, respectively). The P group demonstrated a significant reduction in CRP levels at 45 and 180 days after NSPT compared with baseline (P < 0.05), whereas this reduction was not observed in the CAN/P group. Conclusion: Patients with breast cancer who were undergoing chemotherapy responded to periodontal non-surgical therapy, although with less favorable results than patients with periodontitis without cancer, and may require additional or adjunctive periodontal treatments. (AU)

• FAPESP's process: 12/20971-8 - Assessment of periodontal conditions in women with gynecological cancer under chemotherapy
• Grantee: Daniela Bazan Palioto Bulle
• Support Opportunities: Regular Research Grants