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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cardiac Cachexia: Perspectives for Prevention and Treatment

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Author(s):
Marina Politi Okoshi ; Rafael Verardino Capalbo ; Fernando G Romeiro ; Katashi Okoshi
Total Authors: 4
Document type: Journal article
Source: Arquivos Brasileiros de Cardiologia; v. 108, n. 1, p. 74-80, Jan. 2017.
Web of Science Citations: 11
Abstract

Abstract Cachexia is a prevalent pathological condition associated with chronic heart failure. Its occurrence predicts increased morbidity and mortality independent of important clinical variables such as age, ventricular function, or heart failure functional class. The clinical consequences of cachexia are dependent on both weight loss and systemic inflammation, which accompany cachexia development. Skeletal muscle wasting is an important component of cachexia; it often precedes cachexia development and predicts poor outcome in heart failure. Cachexia clinically affects several organs and systems. It is a multifactorial condition where underlying pathophysiological mechanisms are not completely understood making it difficult to develop specific prevention and treatment therapies. Preventive strategies have largely focused on muscle mass preservation. Different treatment options have been described, mostly in small clinical studies or experimental settings. These include nutritional support, neurohormonal blockade, reducing intestinal bacterial translocation, anemia and iron deficiency treatment, appetite stimulants, immunomodulatory agents, anabolic hormones, and physical exercise regimens. Currently, nonpharmacological therapy such as nutritional support and physical exercise are considered central to cachexia prevention and treatment. (AU)

FAPESP's process: 12/50512-5 - Effects of physical training on throphism and myostatin/follistatin pathway in skeletal and cardiac muscle of spontaneously hypertensive rats with heart failure
Grantee:Marina Politi Okoshi
Support type: Regular Research Grants
FAPESP's process: 14/21972-3 - Influence of physical exercise on oxidative stress and protein expression of MAPK and NF-kB pathways in soleus muscle of rats with aortic stenosis-induced heart failure
Grantee:Marina Politi Okoshi
Support type: Regular Research Grants