Quantifying adsorption of heparin on a PVC substrate using ATR-FTIR

Harada, N. S.; Oyama, H. T.; Bártoli, J. R.; Gouvêa, D.; Cestari, I. A.; Wang, S. H.

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Quantifying adsorption of heparin on a PVC substrate using ATR-FTIR

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Author(s):	Harada, N. S. ; Oyama, H. T. ; Bártoli, J. R. ; Gouvêa, D. ; Cestari, I. A. ; Wang, S. H. ^[6] Total Authors: 6
Document type:	Journal article
Source:	Polymer International; v. 54, n. 1, p. 209-214, Nov. 2004.
Field of knowledge:	Engineering - Materials and Metallurgical Engineering
Abstract
The surface modification of poly(vinyl chloride) (PVC) tubing by heparin was performed to increase its blood compatibility. A solution of benzalkonium heparinate was used in the treatment of two types of plasticized PVC. The modification of the PVC surface was monitored after various treatment conditions, and quantitative results were obtained by using ATR-FTIR spectroscopy. The treatment times and the PVC type have a strong influence on the observed amount of heparin. A partial removal (20-30 %) of heparin was observed after rinsing the PVC surface with a 0.9wt% NaCl aqueous solution. The more flexible PVC tubing, having a lower T-g, had a higher concentration of heparin. Final heparin concentrations on the PVC surfaces were found to be in the range 1-17 mug cm(-2). (AU)

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