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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Marrow adipose tissue spectrum in obesity and type 2 diabetes mellitus

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Author(s):
de Araujo, Iana M. ; Salmon, Carlos E. G. ; Nahas, Andressa K. ; Nogueira-Barbosa, Marcello H. ; Elias, Jr., Jorge ; de Paula, Francisco J. A.
Total Authors: 6
Document type: Journal article
Source: EUROPEAN JOURNAL OF ENDOCRINOLOGY; v. 176, n. 1, p. 21-30, JAN 2017.
Web of Science Citations: 15
Abstract

Objective: To assess the association of bone mass and marrow adipose tissue (MAT) with other fat depots, insulin resistance, bone remodeling markers, adipokines and glucose control in type 2 diabetes and obesity. Design and methods: The study groups comprised 24 controls (C), 26 obese (O) and 28 type 2 diabetes. Dual-energy X-ray absorptiometry was used to determine bone mineral density (BMD). Blood samples were collected for biochemical measurements. H-1 Magnetic resonance spectroscopy was used to assess MAT in the L3 vertebra, and abdominal magnetic resonance imaging was used to assess intrahepatic lipids in visceral (VAT) and subcutaneous adipose tissue. Regression analysis models were used to test the association between parameters. Results: At all sites tested, BMD was higher in type 2 diabetes than in O and C subjects. The C group showed lower VAT values than the type 2 diabetes group and lower IHL than the O and type 2 diabetes groups. However, MAT was similar in the 3 groups. Osteocalcin and C-terminal telopeptide of type 1 collagen were lower in type 2 diabetes than those in C and O subjects. Moreover, at all sites, BMD was negatively associated with osteocalcin. No association was observed between MAT and VAT. No relationship was observed among MAT and HOMA-IR, leptin, adiponectin or Pref-1, but MAT was positively associated with glycated hemoglobin. Conclusions: MAT is not a niche for fat accumulation under conditions of energy surplus and type 2 diabetes, also is not associated with VAT or insulin resistance. MAT is associated with glycated hemoglobin. (AU)

FAPESP's process: 12/09527-9 - The role of bone marrow and visceral fat on bone mineral density and fracture occurrence in type 2 diabetes mellitus
Grantee:Iana Mizumukai de Araujo
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 12/14603-6 - The role of bone marrow and visceral fat on bone mineral density and fracture occurrence in type 2 Diabetes Mellitus
Grantee:Francisco José Albuquerque de Paula
Support Opportunities: Regular Research Grants