Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys

Author(s):Show less -

Abbink, Peter ; Larocca, Rafael A. ; De La Barrera, Rafael A. ; Bricault, Christine A. ; Moseley, Edward T. ; Boyd, Michael ; Kirilova, Marinela ; Li, Zhenfeng ; Ng'ang'a, David ; Nanayakkara, Ovini ; Nityanandam, Ramya ; Mercado, Noe B. ; Borducchi, Erica N. ; Agarwal, Arshi ; Brinkman, Amanda L. ; Cabral, Crystal ; Chandrashekar, Abishek ; Giglio, Patricia B. ; Jetton, David ; Jimenez, Jessica ; Lee, Benjamin C. ; Mojta, Shanell ; Molloy, Katherine ; Shetty, Mayuri ; Neubauer, George H. ; Stephenson, Kathryn E. ; Peron, Jean Pierre S. ; Zanotto, Paolo M. de A. ; Misamore, Johnathan ; Finneyfrock, Brad ; Lewis, Mark G. ; Alter, Galit ; Modjarrad, Kayvon ; Jarman, Richard G. ; Eckels, Kenneth H. ; Michael, Nelson L. ; Thomas, Stephen J. ; Barouch, Dan H.

• Document type: Journal article
• Source: Science; v. 353, n. 6304, p. 1129-1132, SEP 9 2016.
• Web of Science Citations: 227

Abstract

Zika virus (ZIKV) is responsible for a major ongoing epidemic in the Americas and has been causally associated with fetal microcephaly. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Here we demonstrate that three different vaccine platforms protect against ZIKV challenge in rhesus monkeys. A purified inactivated virus vaccine induced ZIKV-specific neutralizing antibodies and completely protected monkeys against ZIKV strains from both Brazil and Puerto Rico. Purified immunoglobulin from vaccinated monkeys also conferred passive protection in adoptive transfer studies. A plasmid DNA vaccine and a single-shot recombinant rhesus adenovirus serotype 52 vector vaccine, both expressing ZIKV premembrane and envelope, also elicited neutralizing antibodies and completely protected monkeys against ZIKV challenge. These data support the rapid clinical development of ZIKV vaccines for humans. (AU)

• FAPESP's process: 14/17766-9 - A systemic approach to study permissivity on the Anticarsia gemmatalis multiple nucleopolyhedrovirus (AgMNPV)
• Grantee: Paolo Marinho de Andrade Zanotto
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/18703-2 - The role of Indoleamine-2,3-dioxigenase and the Triptophan - Kynurenines axis through NMDA receptors over the immune response in the EAE and stroke model
• Grantee: Jean Pierre Schatzmann Peron
• Support Opportunities: Research Grants - Young Investigators Grants