| Full text | |
| Author(s): |
Guilherme Freire Angotti Carrara
[1]
;
Cristovam Scapulatempo-Neto
[2]
;
Lucas Faria Abrahão-Machado
[3]
;
Maria Mitzi Brentani
[4]
;
João Soares Nunes
[5]
;
Maria Aparecida Azevedo Koike Folgueira
[6]
;
René Aloisio da Costa Vieira
Total Authors: 7
|
| Affiliation: | [1] Programa de Pós-Graduação em Oncologia. Hospital de Câncer de Barretos - Brasil
[2] Hospital de Câncer de Barretos. Departamento de Patologia - Brasil
[3] Hospital de Câncer de Barretos. Departamento de Patologia - Brasil
[4] Universidade de São Paulo. Disciplina de Oncologia. Departamento de Radiologia - Brasil
[5] Hospital de Câncer de Barretos. Departamento de Oncologica Clínica - Brasil
[6] Universidade de São Paulo. Disciplina de Oncologia. Departamento de Radiologia - Brasil
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | Clinics; v. 72, n. 3, p. 134-142, 2017-03-00. |
| Abstract | |
OBJECTIVE: To evaluate ipsilateral breast tumor recurrence after breast-conserving surgery for locally advanced breast cancer. METHODS: A retrospective observational cohort study was performed in patients with locally advanced breast cancer submitted to breast-conserving surgery after neoadjuvant chemotherapy based on an adriamycin-cyclophosphamide-paclitaxel regimen. We evaluated the clinical, pathologic, immunohistochemistry, and surgical factors that contribute to ipsilateral breast tumor recurrence and locoregional recurrence. A Kaplan-Meier analysis and Cox model were used to evaluate the main factors related to disease-free survival. RESULTS: Of the 449 patients who received neoadjuvant chemotherapy, 98 underwent breast-conserving surgery. The average diameter of the tumors was 5.3 cm, and 87.2% reached a size of up to 3 cm. Moreover, 86.7% were classified as clinical stage III, 74.5% had T3-T4 tumors, 80.5% had N1-N2 axilla, and 89.8% had invasive ductal carcinoma. A pathologic complete response was observed in 27.6% of the tumors, and 100.0% of samples had free margins. The 5-year actuarial overall survival rate was 81.2%, and the mean follow-up was 72.8 months. The rates of ipsilateral breast tumor recurrence and locoregional recurrence were 11.2% and 15.3%, respectively. Multifocal morphology response was the only factor related to ipsilateral breast tumor recurrence disease-free survival (p=0.04). A multivariate analysis showed that the pathologic response evaluation criteria in solid tumors (RECIST)-breast cutoff was the only factor related to locoregional recurrence disease-free survival (p=0.01). CONCLUSIONS: Breast-conserving surgery is a safe and effective therapy for selected locally advanced breast tumors. (AU) | |
| FAPESP's process: | 12/19642-0 - Clinical and pathological factors related to complete patologic response and local recurrence in patients with locally advanced breast cancer, submitted to neoadjuvant chemotherapy |
| Grantee: | René Aloisio da Costa Vieira |
| Support Opportunities: | Regular Research Grants |