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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bio-based polyurethane for tissue engineering applications: How hydroxyapatite nanoparticles influence the structure, thermal and biological behavior of polyurethane composites

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Gabriel, Lais P. ; dos Santos, Maria Elizabeth M. ; Jardini, Andre L. ; Bastos, Gilmara N. T. ; Dias, Carmen G. B. T. ; Webster, Thomas J. ; Maciel Filho, Rubens
Total Authors: 7
Document type: Journal article
Source: Nanomedicine-Nanotechnology Biology and Medicine; v. 13, n. 1, p. 201-208, JAN 2017.
Web of Science Citations: 12

In this work, thermoset polyurethane composites were prepared by the addition of hydroxyapatite nanoparticles using the reactants polyol polyether and an aliphatic diisocyanate. The polyol employed in this study was extracted from the Euterpe oleracea Mart. seeds from the Amazon Region of Brazil. The influence of hydroxyapatite nanoparticles on the structure and morphology of the composites was studied using scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS), the structure was evaluated by Fourier transform infrared spectroscopy (FT-IR), thermal properties were analyzed by thermogravimetry analysis (TGA), and biological properties were studied by in vitro and in vivo studies. It was found that the addition of HA nanoparticles promoted fibroblast adhesion while in vivo investigations with histology confirmed that the composites promoted connective tissue adherence and did not induce inflammation. In this manner, this study supports the further investigation of bio-based, polyurethane/hydroxyapatite composites as biocompatible scaffolds for numerous tissue engineering applications. (C) 2016 Elsevier Inc. All rights reserved. (AU)