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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Moderate exercise increases endotoxin concentration in hypoxia but not in normoxia A controlled clinical trial

Full text
Author(s):
Machado, Paola ; Caris, Aline ; Santos, Samile ; Silva, Edgar ; Oyama, Lila ; Tufik, Sergio ; Santos, Ronaldo
Total Authors: 7
Document type: Journal article
Source: MEDICINE; v. 96, n. 4 JAN 2017.
Web of Science Citations: 0
Abstract

Background: Hypoxia and high altitudes affect various organs, which impairs important physiological functions, such as a disruption of the intestinal barrier mediated by increased translocation of bacteria and increased circulating endotoxin levels. Physical exercise can alter endotoxin concentration in normoxia. The aim of this study is to evaluate the effects of moderate exercise on endotoxin concentration in normobaric hypoxia. Methods: Nine healthy male volunteers exercised on a treadmill for 60 minutes at an intensity of 50% VO2peak in normoxic or hypoxic conditions (4200 m). Blood was collected at rest, immediately after exercise and 1 hour after exercise to evaluate serum endotoxin levels. Results: Under hypoxic exercise conditions, SaO(2)% saturation was lower after exercise compared with resting levels (P<0.05) and returned to the resting level during recovery in normoxia (P<0.05). Endotoxin concentration increased after exercise in hypoxia (P<0.05); it remained high 1hour after exercise in hypoxia compared with normoxia (P<0.05) and was higher after exercise and recovery compared with resting levels (P<0.05). HR was higher during exercise in relation basal in both conditions (P<0.05) and RPR increase after 60minutes in comparison to 20minutes in hypoxia (P<0.05). Conclusion: Moderate exercise performed in hypoxia equivalent to 4200 m increased endotoxin plasma concentration after exercise. One hour of rest in normoxic conditions was insufficient for the recovery of circulating endotoxins. (AU)

FAPESP's process: 13/01324-4 - Effect of different intensities of exercise in hypoxia upon immunologic and inflammatory parameters
Grantee:Ronaldo Vagner Thomatieli dos Santos
Support Opportunities: Regular Research Grants