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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Transmission between Archaic and Modern Human Ancestors during the Evolution of the Oncogenic Human Papillomavirus 16

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Author(s):
Pimenoff, Ville N. ; Mendes de Oliveira, Cristina ; Bravo, Ignacio G.
Total Authors: 3
Document type: Journal article
Source: Molecular Biology and Evolution; v. 34, n. 1, p. 4-19, JAN 2017.
Web of Science Citations: 26
Abstract

Every human suffers through life a number of papillomaviruses (PVs) infections, most of them asymptomatic. A notable exception are persistent infections by Human papillomavirus 16 (HPV16), the most oncogenic infectious agent for humans and responsible for most infection-driven anogenital cancers. Oncogenic potential is not homogeneous among HPV16 lineages, and genetic variation within HPV16 exhibits some geographic structure. However, an in-depth analysis of the HPV16 evolutionary history was still wanting. We have analyzed extant HPV16 diversity and compared the evolutionary and phylogeographical patterns of humans and of HPV16. We show that codivergence with modern humans explains at most 30% of the present viral geographical distribution. The most explanatory scenario suggests that ancestral HPV16 already infected ancestral human populations and that viral lineages co-diverged with the hosts in parallel with the split between archaic Neanderthal-Denisovans and ancestral modern human populations, generating the ancestral HPV16A and HPV16BCD viral lineages, respectively. We propose that after out-of-Africa migration of modern human ancestors, sexual transmission between human populations introduced HPV16A into modern human ancestor populations. We hypothesize that differential coevolution of HPV16 lineages with different but closely related ancestral human populations and subsequent host-switch events in parallel with introgression of archaic alleles into the genomes of modern human ancestors may be largely responsible for the present-day differential prevalence and association with cancers for HPV16 variants. (AU)

FAPESP's process: 11/24035-2 - Whole genome comparison of HPV-11 and 16 isolates involved in asymptomatic infection, benign and malignant lesions
Grantee:Cristina Mendes de Oliveira
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 12/23290-1 - Whole genome comparison of HPV 11 and 16 isolates involved in asymptomatic infection, benign and malignant lesions
Grantee:Cristina Mendes de Oliveira
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor