| Full text | |
| Author(s): |
Shamim, Anwar
;
Souza, Frederico B.
;
Vasconcelos, Stanley N. S.
;
Stefani, Helio A.
Total Authors: 4
|
| Document type: | Journal article |
| Source: | Tetrahedron Letters; v. 58, n. 9, p. 884-888, MAR 1 2017. |
| Web of Science Citations: | 6 |
| Abstract | |
A library of glucal-derived triazoles have been synthesized using the copper-catalyzed azide-alkyne cyclization reaction starting from 3,4,6-tri-O-acetyl-h-glucal. Different trimethylsilyl substituted alkyne derivatives of glucal were first synthesized from 3,4,6-tri-O-acetyl-D-glucal, using Sonogashira coupling, hydrostannation and iodination steps. These glucal-based trimethylsilyl-protected alkynes were then used in the copper-catalyzed cyclization reactions with different organic azides to synthesize the corresponding triazole derivatives of D-glucal. (C) 2017 Elsevier Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 12/00424-2 - Synthesis of small libraries using potassium Organotrifluoroborates in Suzuki-Miyaura reactions |
| Grantee: | Helio Alexandre Stefani |
| Support Opportunities: | Research Projects - Thematic Grants |