| Full text | |
| Author(s): |
Vasconcelos, Stanley N. S.
;
Beltran Rodrigues, Ana Clara
;
Bastos, Erick Leite
;
Stefani, Helio A.
Total Authors: 4
|
| Document type: | Journal article |
| Source: | CHEMISTRYSELECT; v. 1, n. 6, p. 1287-1291, MAY 1 2016. |
| Web of Science Citations: | 3 |
| Abstract | |
An expeditious ultrasound-assisted synthesis of a tyrosine-tyrosine peptide library is presented. Dipeptide synthesis and functionalization, via Suzuki-Miyaura or Sonogashira cross-coupling reactions, was carried out and led to sixteen extended conjugation derivatives in moderate to good yields. Both o-hydroxy- and o-methoxy-trans-stilbenyl-Tyr-Tyr peptides emit blue fluorescence when irradiated with ultraviolet light. The fluorescence quantum yield of solutions of these peptides in methanol, acetonitrile or THF was 0.20 +/- 0.05. Quantum chemical calculations the Time-Dependent Density Functional Theory (TDDFT) level suggests that, for both peptides, emission originates from the stilbene core. (AU) | |
| FAPESP's process: | 12/00424-2 - Synthesis of small libraries using potassium Organotrifluoroborates in Suzuki-Miyaura reactions |
| Grantee: | Helio Alexandre Stefani |
| Support type: | Research Projects - Thematic Grants |
| FAPESP's process: | 14/14866-2 - Intermolecular interactions involving betalains |
| Grantee: | Erick Leite Bastos |
| Support type: | Regular Research Grants |
| FAPESP's process: | 13/17960-7 - Functionalization of 3-iodo-(L)-Tyrosine via Suzuki-Miyaura reaction using potassium organotrifluoroborate salts |
| Grantee: | Stanley Nunes Siqueira Vasconcelos |
| Support type: | Scholarships in Brazil - Doctorate |