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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Factorial design evaluation of the Suzuki cross-coupling reaction using a CrossMark magnetically recoverable palladium catalyst

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Author(s):
Guerra, Raiza R. G. ; Martins, Felipe C. P. ; Lima, Carolina G. S. ; Goncalves, Ricardo H. ; Leite, Edson R. ; Pereira-Filho, Edenir R. ; Schwab, Ricardo S.
Total Authors: 7
Document type: Journal article
Source: Tetrahedron Letters; v. 58, n. 10, p. 903-908, MAR 8 2017.
Web of Science Citations: 7
Abstract

A magnetically recoverable catalyst {[}Fe3O4@SiO2-AEAPTMS-Pd(II)] was prepared, fully characterized and had its catalytic activity evaluated on the Suzuki cross-coupling reaction under microwave irradiation. The reaction conditions for the synthesis of biaryl compounds was optimized in two stages - an initial fractional design 24, in which the parameters reaction time, temperature, solvent and catalyst loading were evaluated, followed by a Doehlert design. The factorial design proved to be a viable approach for obtaining the optimal reaction conditions based on a relatively small number of experiments. Additionally, the biaryl derivatives synthesized by this method were obtained with good to excellent yields (71-96%) and the recovery and reuse of the palladium catalyst was also evaluated. (AU)

FAPESP's process: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock
Grantee:Arlene Gonçalves Corrêa
Support type: Research Grants - Research Centers in Engineering Program
FAPESP's process: 13/06558-3 - Asymmetric catalysis: preparation of chiral alcohols and their derivatives from highly functionalized organozinc reagents and application of new chiral ligands supported on magnetic nanoparticles
Grantee:Ricardo Samuel Schwab
Support type: Regular Research Grants