Asymmetric catalysis: preparation of chiral alcohols and their derivatives from hi...
| Full text | |
| Author(s): |
Guerra, Raiza R. G.
;
Martins, Felipe C. P.
;
Lima, Carolina G. S.
;
Goncalves, Ricardo H.
;
Leite, Edson R.
;
Pereira-Filho, Edenir R.
;
Schwab, Ricardo S.
Total Authors: 7
|
| Document type: | Journal article |
| Source: | Tetrahedron Letters; v. 58, n. 10, p. 903-908, MAR 8 2017. |
| Web of Science Citations: | 7 |
| Abstract | |
A magnetically recoverable catalyst {[}Fe3O4@SiO2-AEAPTMS-Pd(II)] was prepared, fully characterized and had its catalytic activity evaluated on the Suzuki cross-coupling reaction under microwave irradiation. The reaction conditions for the synthesis of biaryl compounds was optimized in two stages - an initial fractional design 24, in which the parameters reaction time, temperature, solvent and catalyst loading were evaluated, followed by a Doehlert design. The factorial design proved to be a viable approach for obtaining the optimal reaction conditions based on a relatively small number of experiments. Additionally, the biaryl derivatives synthesized by this method were obtained with good to excellent yields (71-96%) and the recovery and reuse of the palladium catalyst was also evaluated. (AU) | |
| FAPESP's process: | 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock |
| Grantee: | Arlene Gonçalves Corrêa |
| Support type: | Research Grants - Research Centers in Engineering Program |
| FAPESP's process: | 13/06558-3 - Asymmetric catalysis: preparation of chiral alcohols and their derivatives from highly functionalized organozinc reagents and application of new chiral ligands supported on magnetic nanoparticles |
| Grantee: | Ricardo Samuel Schwab |
| Support type: | Regular Research Grants |