Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

Ghezzi, Silvia; Cooper, Lynsay; Rubio, Alicia; Pagani, Isabel; Capobianchi, Maria Rosaria; Ippolito, Giuseppe; Pelletier, Julien; Meneghetti, Maria Cecilia Z.; Lima, Marcelo A.; Skidmore, Mark A.; Broccoli, Vania; Yates, Edwin A.; Vicenzi, Elisa

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

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Author(s): Show less -	Ghezzi, Silvia ; Cooper, Lynsay ; Rubio, Alicia ; Pagani, Isabel ; Capobianchi, Maria Rosaria ; Ippolito, Giuseppe ; Pelletier, Julien ; Meneghetti, Maria Cecilia Z. ; Lima, Marcelo A. ; Skidmore, Mark A. ; Broccoli, Vania ; Yates, Edwin A. ; Vicenzi, Elisa Total Authors: 13
Document type:	Journal article
Source:	Antiviral Research; v. 140, p. 13-17, APR 2017.
Web of Science Citations:	11
Abstract
The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs). (C) 2017 Elsevier B.V. All rights reserved. (AU)

FAPESP's process:	15/08782-3 - Structural and functional dynamics of heparin sulfate
Grantee:	Marcelo Andrade de Lima
Support Opportunities:	Regular Research Grants

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